PinnyPeptide

Colivelin vs Selank

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Peptide B

Selank

Cognitive

Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~15-30 minutes (extended biological effect due to downstream signaling)

FDA status

Not FDA approved for human use.

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

Selank effects

  • Reduces anxiety without sedation or cognitive impairment
  • Enhances memory consolidation and learning
  • Modulates serotonin, dopamine, and GABA neurotransmitter systems
  • Provides immunomodulatory effects through cytokine balance regulation
  • Increases brain-derived neurotrophic factor (BDNF) expression

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

Selank side effects

  • Mild nasal irritation (intranasal administration)
  • Fatigue during initial use (transient)
  • Occasional lightheadedness

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

Selank dosing ranges

Anxiolytic and cognitive enhancement (intranasal)

250-500 mcg · Two to three times daily · 2-4 weeks

Subcutaneous injection

250-500 mcg · Once daily · 2-4 weeks

Full Colivelin guide → Full Selank guide →

Colivelin vs Selank — common questions

What is the difference between Colivelin and Selank?

Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. Selank: Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties. Typical dose 250-500 mcg. Both fall under the Cognitive category.

Can you stack Colivelin and Selank?

Stacking Colivelin with Selank is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Colivelin or Selank?

Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research. Selank is typically dosed: Two to three times daily for Anxiolytic and cognitive enhancement (intranasal); Once daily for Subcutaneous injection.

Are Colivelin and Selank FDA approved?

Colivelin: Not FDA approved. Selank: Not FDA approved for human use.

Related peptide comparisons

adamax vs colivelincolivelin vs dihexacolivelin vs dnsp-11colivelin vs p21colivelin vs pe22-28colivelin vs pinealon

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free