PinnyPeptide

Adamax vs Colivelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Adamax

Cognitive

Adamantyl-capped Semax derivative — a more lipophilic, longer-acting nootropic analog.

Peptide B

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Typical vial

5 mg

Typical dose

100-500 mcg

Half-life

Estimated longer than Semax (~hours, uncharacterized)

FDA status

Not FDA approved.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Adamax effects

  • Hypothesized BDNF upregulation in hippocampus / cortex
  • Theoretical longer duration of action vs. Semax
  • Theoretical improved blood-brain barrier penetration
  • Cognitive enhancement claims (attention, memory)
  • Mood and stress-resilience effects (extrapolated from Semax)

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

Adamax side effects

  • Largely uncharacterized in published literature
  • By analogy with Semax: mild headache, sleep disturbance, irritability at high doses
  • Theoretical: adamantyl-related effects on dopamine signaling
  • Injection-site or intranasal irritation

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

Adamax dosing ranges

Cognitive research (intranasal)

100-300 mcg · Once or twice daily · 14-30 days per cycle

Subcutaneous research

100-500 mcg · Once daily · 14-30 days per cycle

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

Full Adamax guide → Full Colivelin guide →

Adamax vs Colivelin — common questions

What is the difference between Adamax and Colivelin?

Adamax: Adamantyl-capped Semax derivative — a more lipophilic, longer-acting nootropic analog. Typical dose 100-500 mcg. Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. Both fall under the Cognitive category.

Can you stack Adamax and Colivelin?

Stacking Adamax with Colivelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Adamax or Colivelin?

Adamax is typically dosed: Once or twice daily for Cognitive research (intranasal); Once daily for Subcutaneous research. Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research.

Are Adamax and Colivelin FDA approved?

Adamax: Not FDA approved. Colivelin: Not FDA approved.

Related peptide comparisons

acth-1-39 vs adamaxadamax vs dihexaadamax vs dnsp-11adamax vs p21adamax vs pe22-28colivelin vs dihexa

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free