Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Cognitive
Adamantyl-capped Semax derivative — a more lipophilic, longer-acting nootropic analog.
Peptide B
Cognitive
Fast-acting antidepressant peptide acting via TREK-1 channel inhibition.
Typical vial
5 mg
Typical dose
100-500 mcg
Half-life
Estimated longer than Semax (~hours, uncharacterized)
FDA status
Not FDA approved.
Typical vial
5 mg
Typical dose
50-200 mcg
Half-life
Hours; precise value species-dependent
FDA status
Not FDA approved.
Adamax effects
PE22-28 effects
Adamax side effects
PE22-28 side effects
Adamax dosing ranges
Cognitive research (intranasal)
100-300 mcg · Once or twice daily · 14-30 days per cycle
Subcutaneous research
100-500 mcg · Once daily · 14-30 days per cycle
PE22-28 dosing ranges
Antidepressant research (preclinical)
100-500 mcg/kg · Daily SubQ or IP · Per protocol
Self-experimentation (no clinical guidance)
50-200 mcg · Once or twice daily · 2-4 weeks per cycle
Adamax: Adamantyl-capped Semax derivative — a more lipophilic, longer-acting nootropic analog. Typical dose 100-500 mcg. PE22-28: Fast-acting antidepressant peptide acting via TREK-1 channel inhibition. Typical dose 50-200 mcg. Both fall under the Cognitive category.
Stacking Adamax with PE22-28 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
Adamax is typically dosed: Once or twice daily for Cognitive research (intranasal); Once daily for Subcutaneous research. PE22-28 is typically dosed: Daily SubQ or IP for Antidepressant research (preclinical); Once or twice daily for Self-experimentation (no clinical guidance).
Adamax: Not FDA approved. PE22-28: Not FDA approved.
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