PinnyPeptide

Colivelin vs Dihexa

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Peptide B

Dihexa

Cognitive

Hepatocyte growth factor mimetic — claimed to be 7 orders of magnitude more potent than BDNF.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Typical vial

30 mg

Typical dose

8,000-45,000 (oral) mcg

Half-life

~3-4 hours (oral)

FDA status

Not FDA approved. The related HGF-positive modulator fosgoni…

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

Dihexa effects

  • Claimed promotion of dendritic spine formation
  • HGF / c-Met signaling enhancement
  • Procognitive effects in rodent models
  • Orally bioavailable (rare for peptides)
  • Anecdotal cognitive enhancement in human users

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

Dihexa side effects

  • Essentially uncharacterized in humans
  • Headache (commonly reported in self-experimentation)
  • Increased emotionality / mood changes (subjective reports)
  • Theoretical: pro-oncogenic concerns via HGF / c-Met activation
  • Insomnia with late-day dosing

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

Dihexa dosing ranges

Cognitive research (oral / sublingual)

8-45 mg · Once daily · 30 days per cycle

Full Colivelin guide → Full Dihexa guide →

Colivelin vs Dihexa — common questions

What is the difference between Colivelin and Dihexa?

Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. Dihexa: Hepatocyte growth factor mimetic — claimed to be 7 orders of magnitude more potent than BDNF. Typical dose 8,000-45,000 (oral) mcg. Both fall under the Cognitive category.

Can you stack Colivelin and Dihexa?

Stacking Colivelin with Dihexa is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Colivelin or Dihexa?

Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research. Dihexa is typically dosed: Once daily for Cognitive research (oral / sublingual).

Are Colivelin and Dihexa FDA approved?

Colivelin: Not FDA approved. Dihexa: Not FDA approved. The related HGF-positive modulator fosgonimeton (ATH-1017) is in clinical trials for Alzheimer's.

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