PinnyPeptide

Colivelin vs P21 (P021)

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Peptide B

P21 (P021)

Cognitive

Neurogenic, anti-tau peptide derived from ciliary neurotrophic factor — Alzheimer's research.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

Per kg dosing mcg

Half-life

Variable; designed for sustained activity

FDA status

Not FDA approved.

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

P21 (P021) effects

  • Promotes adult hippocampal neurogenesis
  • Increases dendritic spine density
  • Reduces tau hyperphosphorylation (anti-tauopathy)
  • Improves learning and memory in Alzheimer's mouse models
  • Crosses the blood-brain barrier after peripheral administration

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

P21 (P021) side effects

  • Essentially uncharacterized in humans
  • Theoretical: off-target effects on CNTF / leptin receptor pathways
  • Possible effects on appetite and metabolism (CNTF-family signaling)
  • Injection-site reactions

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

P21 (P021) dosing ranges

Neurogenesis research (preclinical)

40-200 mcg/kg · Daily or alternate-day SubQ · Per research protocol

Full Colivelin guide → Full P21 (P021) guide →

Colivelin vs P21 (P021) — common questions

What is the difference between Colivelin and P21 (P021)?

Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. P21 (P021): Neurogenic, anti-tau peptide derived from ciliary neurotrophic factor — Alzheimer's research. Typical dose Per kg dosing mcg. Both fall under the Cognitive category.

Can you stack Colivelin and P21 (P021)?

Stacking Colivelin with P21 (P021) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Colivelin or P21 (P021)?

Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research. P21 (P021) is typically dosed: Daily or alternate-day SubQ for Neurogenesis research (preclinical).

Are Colivelin and P21 (P021) FDA approved?

Colivelin: Not FDA approved. P21 (P021): Not FDA approved.

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