PinnyPeptide

Colivelin vs Pinealon

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Peptide B

Pinealon

Cognitive

Neuroprotective tripeptide bioregulator that penetrates the nuclear membrane to directly regulate gene expression in brain tissue.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Typical vial

20 mg

Typical dose

100-500 mcg

Half-life

~1-2 hours (estimated; formal pharmacokinetic data in humans is not published — biological effects on gene expression persist beyond plasma clearance)

FDA status

Not FDA approved. No IND or NDA has been submitted to the FD…

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

Pinealon effects

  • Suppresses reactive oxygen species (ROS) accumulation in neuronal cells, reducing oxidative stress-driven cell death
  • Preserves dendritic spine morphology in models of Alzheimer's and Huntington's disease, protecting synaptic integrity
  • Modulates gene expression via direct nuclear membrane penetration, regulating genes involved in neuronal survival (SOD2, GPX1, CASP3, APOE)
  • Supports serotonin biosynthesis by promoting 5-tryptophan hydroxylase expression, with potential mood-regulatory effects
  • Reduces apoptotic signaling in neurons by downregulating pro-apoptotic proteins including caspase-3
  • Reported improvement in memory, cognitive performance, and reduced headache duration in patients with traumatic brain injury sequelae

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

Pinealon side effects

  • Injection site reactions: mild redness, itching, or transient swelling at subcutaneous injection site
  • Headache or mild dizziness, particularly early in a dosing cycle
  • Vivid dreams or mild sleep disturbance if administered late in the day (likely related to CNS activity)
  • Gastrointestinal discomfort (more commonly reported with oral capsule form)
  • Rare: transient mild anxiety or fatigue; allergic hypersensitivity reactions are possible but not well-documented in the literature

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

Pinealon dosing ranges

Cognitive support and neuroprotection (subcutaneous)

100-500 mcg · Once daily · 10-20 days per cycle, repeated 2-4 times per year

Traumatic brain injury sequelae / cerebral asthenia (oral, clinical study protocol)

0.2 mg (200 mcg) twice daily · Twice daily · 20-30 days

General anti-aging and brain longevity (oral supplement)

10-20 mg per day (1-2 capsules of 10 mg each) · Once or twice daily, 30 minutes before meals · 1 month on, then reassess

Full Colivelin guide → Full Pinealon guide →

Colivelin vs Pinealon — common questions

What is the difference between Colivelin and Pinealon?

Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. Pinealon: Neuroprotective tripeptide bioregulator that penetrates the nuclear membrane to directly regulate gene expression in brain tissue. Typical dose 100-500 mcg. Both fall under the Cognitive category.

Can you stack Colivelin and Pinealon?

Stacking Colivelin with Pinealon is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Colivelin or Pinealon?

Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research. Pinealon is typically dosed: Once daily for Cognitive support and neuroprotection (subcutaneous); Twice daily for Traumatic brain injury sequelae / cerebral asthenia (oral, clinical study protocol); Once or twice daily, 30 minutes before meals for General anti-aging and brain longevity (oral supplement).

Are Colivelin and Pinealon FDA approved?

Colivelin: Not FDA approved. Pinealon: Not FDA approved. No IND or NDA has been submitted to the FDA. Classified as a research chemical in the United States.

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