PinnyPeptide

LL-37 vs TB-500 Fragment 17-23

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

LL-37

Healing & Recovery

Human antimicrobial peptide with broad-spectrum pathogen defense and wound-healing activity.

Peptide B

TB-500 Fragment 17-23

Healing & Recovery

The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects.

Typical vial

5 mg

Typical dose

50-100 mcg

Half-life

~15-30 minutes (rapidly degraded by proteases)

FDA status

Not FDA approved for human use.

Typical vial

10 mg

Typical dose

2000-5000 mcg

Half-life

Estimated minutes to a few hours (much shorter than full TB-500 due to lack of N/C-terminal protection)

FDA status

Not FDA approved for any human or veterinary use. No clinica…

LL-37 effects

  • Broad-spectrum antimicrobial activity against bacteria, fungi, and viruses
  • Disrupts biofilm formation
  • Promotes wound healing and angiogenesis
  • Modulates innate immune responses
  • Neutralizes bacterial endotoxins (LPS)

TB-500 Fragment 17-23 effects

  • Binds G-actin and modulates actin polymerization
  • In vitro promotion of keratinocyte and endothelial cell migration
  • Pro-angiogenic activity in cell-based assays
  • Pro-healing effects on cultured fibroblasts
  • Anti-inflammatory effects (limited to in vitro evidence)
  • Potentially shared but reduced systemic activity vs full TB-500

LL-37 side effects

  • Injection site redness and irritation
  • Potential cytotoxicity at high concentrations
  • Possible mast cell activation
  • Localized skin reactions

TB-500 Fragment 17-23 side effects

  • Injection site irritation or redness
  • Lethargy (anecdotal, mechanism unclear)
  • Mild flu-like symptoms at higher doses (rare)
  • Headache
  • Unknown long-term effects — no human safety data

LL-37 dosing ranges

Antimicrobial support

50-100 mcg · Once daily (SubQ) · 2-4 weeks

Wound healing support

50-100 mcg · Once daily near affected area · 2-4 weeks

TB-500 Fragment 17-23 dosing ranges

Injury recovery (extrapolated)

2-5 mg · Twice weekly SubQ · 4-6 weeks

Tendon/ligament support (extrapolated)

2-5 mg · Twice weekly SubQ · 4-8 weeks

Loading phase (anecdotal)

5 mg · Twice weekly for 2-3 weeks · Then maintenance

Full LL-37 guide → Full TB-500 Fragment 17-23 guide →

LL-37 vs TB-500 Fragment 17-23 — common questions

What is the difference between LL-37 and TB-500 Fragment 17-23?

LL-37: Human antimicrobial peptide with broad-spectrum pathogen defense and wound-healing activity. Typical dose 50-100 mcg. TB-500 Fragment 17-23: The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects. Typical dose 2000-5000 mcg. Both fall under the Healing & Recovery category.

Can you stack LL-37 and TB-500 Fragment 17-23?

Stacking LL-37 with TB-500 Fragment 17-23 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, LL-37 or TB-500 Fragment 17-23?

LL-37 is typically dosed: Once daily (SubQ) for Antimicrobial support; Once daily near affected area for Wound healing support. TB-500 Fragment 17-23 is typically dosed: Twice weekly SubQ for Injury recovery (extrapolated); Twice weekly SubQ for Tendon/ligament support (extrapolated); Twice weekly for 2-3 weeks for Loading phase (anecdotal).

Are LL-37 and TB-500 Fragment 17-23 FDA approved?

LL-37: Not FDA approved for human use. TB-500 Fragment 17-23: Not FDA approved for any human or veterinary use. No clinical trials have been conducted on this specific fragment.

Related peptide comparisons

bpc-157 vs ll-37kpv vs ll-37ll-37 vs tb-500ll-37 vs thymosin-alpha-1ara-290 vs tb-500-frag-17-23bpc-157 vs tb-500-frag-17-23

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