PinnyPeptide

BPC-157 vs LL-37

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

BPC-157

Healing & Recovery

Gastric pentadecapeptide with broad tissue-healing properties.

Peptide B

LL-37

Healing & Recovery

Human antimicrobial peptide with broad-spectrum pathogen defense and wound-healing activity.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~4 hours (estimated from animal pharmacokinetic data)

FDA status

Not FDA approved for human use. FDA issued a warning letter …

Typical vial

5 mg

Typical dose

50-100 mcg

Half-life

~15-30 minutes (rapidly degraded by proteases)

FDA status

Not FDA approved for human use.

BPC-157 effects

  • Accelerates tendon, ligament, and muscle healing
  • Protects and heals the gastrointestinal lining
  • Promotes angiogenesis and new blood vessel formation
  • Reduces inflammation via nitric oxide modulation
  • Exhibits neuroprotective properties
  • Upregulates growth hormone receptor expression in fibroblasts

LL-37 effects

  • Broad-spectrum antimicrobial activity against bacteria, fungi, and viruses
  • Disrupts biofilm formation
  • Promotes wound healing and angiogenesis
  • Modulates innate immune responses
  • Neutralizes bacterial endotoxins (LPS)

BPC-157 side effects

  • Nausea at higher doses
  • Dizziness or lightheadedness
  • Injection site redness or irritation
  • Headache

LL-37 side effects

  • Injection site redness and irritation
  • Potential cytotoxicity at high concentrations
  • Possible mast cell activation
  • Localized skin reactions

BPC-157 dosing ranges

General tissue repair

250-500 mcg · Once or twice daily · 4-6 weeks

Gut healing

250-500 mcg · Twice daily (oral or SubQ) · 4-8 weeks

Acute injury recovery

500 mcg · Twice daily near injury site · 2-4 weeks

LL-37 dosing ranges

Antimicrobial support

50-100 mcg · Once daily (SubQ) · 2-4 weeks

Wound healing support

50-100 mcg · Once daily near affected area · 2-4 weeks

BPC-157 vs LL-37 — common questions

What is the difference between BPC-157 and LL-37?

BPC-157: Gastric pentadecapeptide with broad tissue-healing properties. Typical dose 250-500 mcg. LL-37: Human antimicrobial peptide with broad-spectrum pathogen defense and wound-healing activity. Typical dose 50-100 mcg. Both fall under the Healing & Recovery category.

Can you stack BPC-157 and LL-37?

Stacking BPC-157 with LL-37 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, BPC-157 or LL-37?

BPC-157 is typically dosed: Once or twice daily for General tissue repair; Twice daily (oral or SubQ) for Gut healing; Twice daily near injury site for Acute injury recovery. LL-37 is typically dosed: Once daily (SubQ) for Antimicrobial support; Once daily near affected area for Wound healing support.

Are BPC-157 and LL-37 FDA approved?

BPC-157: Not FDA approved for human use. FDA issued a warning letter in 2024 regarding compounded BPC-157 products. LL-37: Not FDA approved for human use.

Tracking either of these?

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