PinnyPeptide

ARA-290 (Cibinetide) vs BPC-157

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

ARA-290 (Cibinetide)

Healing & Recovery

Tissue-protective helix-B fragment of erythropoietin — without the red-blood-cell effects.

Peptide B

BPC-157

Healing & Recovery

Gastric pentadecapeptide with broad tissue-healing properties.

Typical vial

8 mg

Typical dose

2,000-8,000 mcg

Half-life

~2 minutes (plasma); longer functional duration via receptor binding

FDA status

Not FDA approved. In clinical development by Araim Pharmaceu…

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~4 hours (estimated from animal pharmacokinetic data)

FDA status

Not FDA approved for human use. FDA issued a warning letter …

ARA-290 (Cibinetide) effects

  • Activates the innate repair receptor (IRR / EpoR-βcR heterodimer)
  • Reduces tissue inflammation in injury models
  • Promotes axonal regeneration in small-fiber neuropathy
  • Does NOT raise hemoglobin or platelet count
  • Tissue-protective in ischemia-reperfusion models

BPC-157 effects

  • Accelerates tendon, ligament, and muscle healing
  • Protects and heals the gastrointestinal lining
  • Promotes angiogenesis and new blood vessel formation
  • Reduces inflammation via nitric oxide modulation
  • Exhibits neuroprotective properties
  • Upregulates growth hormone receptor expression in fibroblasts

ARA-290 (Cibinetide) side effects

  • Generally well-tolerated in clinical trials
  • Injection-site reactions (mild)
  • No erythropoietic effects (deliberate design)
  • Long-term safety with chronic dosing still being characterized

BPC-157 side effects

  • Nausea at higher doses
  • Dizziness or lightheadedness
  • Injection site redness or irritation
  • Headache

ARA-290 (Cibinetide) dosing ranges

Small-fiber neuropathy / nerve healing

2-8 mg · Once daily (SubQ) · 4-12 weeks per cycle

General tissue protection research

1-4 mg · Daily or alternate-day · Per research protocol

BPC-157 dosing ranges

General tissue repair

250-500 mcg · Once or twice daily · 4-6 weeks

Gut healing

250-500 mcg · Twice daily (oral or SubQ) · 4-8 weeks

Acute injury recovery

500 mcg · Twice daily near injury site · 2-4 weeks

ARA-290 (Cibinetide) vs BPC-157 — common questions

What is the difference between ARA-290 (Cibinetide) and BPC-157?

ARA-290 (Cibinetide): Tissue-protective helix-B fragment of erythropoietin — without the red-blood-cell effects. Typical dose 2,000-8,000 mcg. BPC-157: Gastric pentadecapeptide with broad tissue-healing properties. Typical dose 250-500 mcg. Both fall under the Healing & Recovery category.

Can you stack ARA-290 (Cibinetide) and BPC-157?

Stacking ARA-290 (Cibinetide) with BPC-157 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, ARA-290 (Cibinetide) or BPC-157?

ARA-290 (Cibinetide) is typically dosed: Once daily (SubQ) for Small-fiber neuropathy / nerve healing; Daily or alternate-day for General tissue protection research. BPC-157 is typically dosed: Once or twice daily for General tissue repair; Twice daily (oral or SubQ) for Gut healing; Twice daily near injury site for Acute injury recovery.

Are ARA-290 (Cibinetide) and BPC-157 FDA approved?

ARA-290 (Cibinetide): Not FDA approved. In clinical development by Araim Pharmaceuticals. Granted orphan drug designation for sarcoidosis-related conditions. BPC-157: Not FDA approved for human use. FDA issued a warning letter in 2024 regarding compounded BPC-157 products.

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free