Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Healing & Recovery
Tissue-protective helix-B fragment of erythropoietin — without the red-blood-cell effects.
Peptide B
Healing & Recovery
The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects.
Typical vial
8 mg
Typical dose
2,000-8,000 mcg
Half-life
~2 minutes (plasma); longer functional duration via receptor binding
FDA status
Not FDA approved. In clinical development by Araim Pharmaceu…
Typical vial
10 mg
Typical dose
2000-5000 mcg
Half-life
Estimated minutes to a few hours (much shorter than full TB-500 due to lack of N/C-terminal protection)
FDA status
Not FDA approved for any human or veterinary use. No clinica…
ARA-290 (Cibinetide) effects
TB-500 Fragment 17-23 effects
ARA-290 (Cibinetide) side effects
TB-500 Fragment 17-23 side effects
ARA-290 (Cibinetide) dosing ranges
Small-fiber neuropathy / nerve healing
2-8 mg · Once daily (SubQ) · 4-12 weeks per cycle
General tissue protection research
1-4 mg · Daily or alternate-day · Per research protocol
TB-500 Fragment 17-23 dosing ranges
Injury recovery (extrapolated)
2-5 mg · Twice weekly SubQ · 4-6 weeks
Tendon/ligament support (extrapolated)
2-5 mg · Twice weekly SubQ · 4-8 weeks
Loading phase (anecdotal)
5 mg · Twice weekly for 2-3 weeks · Then maintenance
ARA-290 (Cibinetide): Tissue-protective helix-B fragment of erythropoietin — without the red-blood-cell effects. Typical dose 2,000-8,000 mcg. TB-500 Fragment 17-23: The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects. Typical dose 2000-5000 mcg. Both fall under the Healing & Recovery category.
Stacking ARA-290 (Cibinetide) with TB-500 Fragment 17-23 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
ARA-290 (Cibinetide) is typically dosed: Once daily (SubQ) for Small-fiber neuropathy / nerve healing; Daily or alternate-day for General tissue protection research. TB-500 Fragment 17-23 is typically dosed: Twice weekly SubQ for Injury recovery (extrapolated); Twice weekly SubQ for Tendon/ligament support (extrapolated); Twice weekly for 2-3 weeks for Loading phase (anecdotal).
ARA-290 (Cibinetide): Not FDA approved. In clinical development by Araim Pharmaceuticals. Granted orphan drug designation for sarcoidosis-related conditions. TB-500 Fragment 17-23: Not FDA approved for any human or veterinary use. No clinical trials have been conducted on this specific fragment.
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