PinnyPeptide

BPC-157 vs TB-500 Fragment 17-23

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

BPC-157

Healing & Recovery

Gastric pentadecapeptide with broad tissue-healing properties.

Peptide B

TB-500 Fragment 17-23

Healing & Recovery

The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~4 hours (estimated from animal pharmacokinetic data)

FDA status

Not FDA approved for human use. FDA issued a warning letter …

Typical vial

10 mg

Typical dose

2000-5000 mcg

Half-life

Estimated minutes to a few hours (much shorter than full TB-500 due to lack of N/C-terminal protection)

FDA status

Not FDA approved for any human or veterinary use. No clinica…

BPC-157 effects

  • Accelerates tendon, ligament, and muscle healing
  • Protects and heals the gastrointestinal lining
  • Promotes angiogenesis and new blood vessel formation
  • Reduces inflammation via nitric oxide modulation
  • Exhibits neuroprotective properties
  • Upregulates growth hormone receptor expression in fibroblasts

TB-500 Fragment 17-23 effects

  • Binds G-actin and modulates actin polymerization
  • In vitro promotion of keratinocyte and endothelial cell migration
  • Pro-angiogenic activity in cell-based assays
  • Pro-healing effects on cultured fibroblasts
  • Anti-inflammatory effects (limited to in vitro evidence)
  • Potentially shared but reduced systemic activity vs full TB-500

BPC-157 side effects

  • Nausea at higher doses
  • Dizziness or lightheadedness
  • Injection site redness or irritation
  • Headache

TB-500 Fragment 17-23 side effects

  • Injection site irritation or redness
  • Lethargy (anecdotal, mechanism unclear)
  • Mild flu-like symptoms at higher doses (rare)
  • Headache
  • Unknown long-term effects — no human safety data

BPC-157 dosing ranges

General tissue repair

250-500 mcg · Once or twice daily · 4-6 weeks

Gut healing

250-500 mcg · Twice daily (oral or SubQ) · 4-8 weeks

Acute injury recovery

500 mcg · Twice daily near injury site · 2-4 weeks

TB-500 Fragment 17-23 dosing ranges

Injury recovery (extrapolated)

2-5 mg · Twice weekly SubQ · 4-6 weeks

Tendon/ligament support (extrapolated)

2-5 mg · Twice weekly SubQ · 4-8 weeks

Loading phase (anecdotal)

5 mg · Twice weekly for 2-3 weeks · Then maintenance

BPC-157 vs TB-500 Fragment 17-23 — common questions

What is the difference between BPC-157 and TB-500 Fragment 17-23?

BPC-157: Gastric pentadecapeptide with broad tissue-healing properties. Typical dose 250-500 mcg. TB-500 Fragment 17-23: The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects. Typical dose 2000-5000 mcg. Both fall under the Healing & Recovery category.

Can you stack BPC-157 and TB-500 Fragment 17-23?

Stacking BPC-157 with TB-500 Fragment 17-23 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, BPC-157 or TB-500 Fragment 17-23?

BPC-157 is typically dosed: Once or twice daily for General tissue repair; Twice daily (oral or SubQ) for Gut healing; Twice daily near injury site for Acute injury recovery. TB-500 Fragment 17-23 is typically dosed: Twice weekly SubQ for Injury recovery (extrapolated); Twice weekly SubQ for Tendon/ligament support (extrapolated); Twice weekly for 2-3 weeks for Loading phase (anecdotal).

Are BPC-157 and TB-500 Fragment 17-23 FDA approved?

BPC-157: Not FDA approved for human use. FDA issued a warning letter in 2024 regarding compounded BPC-157 products. TB-500 Fragment 17-23: Not FDA approved for any human or veterinary use. No clinical trials have been conducted on this specific fragment.

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free