PinnyPeptide

FOX04-DRI vs NAD+ (Injectable)

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

FOX04-DRI

Longevity

D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption.

Peptide B

NAD+ (Injectable)

Longevity

Central cellular cofactor — supplemented to support mitochondrial function and sirtuin activity.

Typical vial

10 mg

Typical dose

Per kg dosing (research) mcg

Half-life

Extended via DRI backbone (~hours-days)

FDA status

Not FDA approved. In preclinical / early clinical developmen…

Typical vial

500 mg

Typical dose

50-200 mg (SubQ); 500-1500 mg (IV) mcg

Half-life

~6-10 hours (cellular turnover)

FDA status

Not FDA approved as a therapeutic. Available via compounding…

FOX04-DRI effects

  • Selective induction of apoptosis in senescent cells
  • Reduction of senescence-associated secretory phenotype (SASP)
  • Rejuvenation effects in aged mouse models (single study)
  • Mechanistically based on FOXO4-p53 binding disruption
  • D-retro-inverso backbone provides enzymatic stability

NAD+ (Injectable) effects

  • Raises cellular NAD+ levels
  • Supports mitochondrial function via electron transport chain
  • Substrate for sirtuin enzymes (deacetylases linked to longevity)
  • Substrate for PARP enzymes (DNA repair)
  • Substrate for CD38 (immune signaling)
  • Subjective reports of energy, mental clarity, mood

FOX04-DRI side effects

  • Largely uncharacterized in humans
  • Theoretical: off-target apoptosis in non-senescent cells under p53 stress
  • Injection-site reactions
  • Possible effects on stem/progenitor cell populations
  • Acute inflammatory response from senescent-cell debris

NAD+ (Injectable) side effects

  • Flushing during IV infusion (most common, mild)
  • Nausea, chest pressure, abdominal discomfort with rapid infusion
  • Headache
  • Subcutaneous: injection-site irritation
  • Possible methylation depletion with chronic high doses

FOX04-DRI dosing ranges

Senolytic research (research-only)

0.4-5 mg/kg · Every other day for 1-2 weeks per cycle · Cycle-based per protocol

NAD+ (Injectable) dosing ranges

IV anti-aging clinic protocol

500-1500 mg · Per infusion, weekly to monthly · Cycle-based

Subcutaneous wellness

50-200 mg · Daily or alternate-day · 2-4 week cycles

Intranasal

20-100 mg · Daily · Cycle-based

Full FOX04-DRI guide → Full NAD+ (Injectable) guide →

FOX04-DRI vs NAD+ (Injectable) — common questions

What is the difference between FOX04-DRI and NAD+ (Injectable)?

FOX04-DRI: D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption. Typical dose Per kg dosing (research) mcg. NAD+ (Injectable): Central cellular cofactor — supplemented to support mitochondrial function and sirtuin activity. Typical dose 50-200 mg (SubQ); 500-1500 mg (IV) mcg. Both fall under the Longevity category.

Can you stack FOX04-DRI and NAD+ (Injectable)?

Stacking FOX04-DRI with NAD+ (Injectable) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, FOX04-DRI or NAD+ (Injectable)?

FOX04-DRI is typically dosed: Every other day for 1-2 weeks per cycle for Senolytic research (research-only). NAD+ (Injectable) is typically dosed: Per infusion, weekly to monthly for IV anti-aging clinic protocol; Daily or alternate-day for Subcutaneous wellness; Daily for Intranasal.

Are FOX04-DRI and NAD+ (Injectable) FDA approved?

FOX04-DRI: Not FDA approved. In preclinical / early clinical development as Proxofim (Cleara Biotech). NAD+ (Injectable): Not FDA approved as a therapeutic. Available via compounding pharmacies for off-label use. NAD+ precursors (NR as Niagen, NMN) sold as dietary supplements.

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