PinnyPeptide

Epithalon vs FOX04-DRI

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Epithalon

Longevity

Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production.

Peptide B

FOX04-DRI

Longevity

D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption.

Typical vial

10 mg

Typical dose

5000-10000 mcg

Half-life

~30 minutes (short half-life but biological effects persist due to gene expression changes)

FDA status

Not FDA approved for human use. No clinical trials submitted…

Typical vial

10 mg

Typical dose

Per kg dosing (research) mcg

Half-life

Extended via DRI backbone (~hours-days)

FDA status

Not FDA approved. In preclinical / early clinical developmen…

Epithalon effects

  • Activates telomerase enzyme to elongate telomeres
  • Restores melatonin production in the pineal gland
  • Regulates neuroendocrine function and circadian rhythms
  • Reduces incidence of spontaneous tumors in animal models
  • Modulates gene expression patterns associated with aging

FOX04-DRI effects

  • Selective induction of apoptosis in senescent cells
  • Reduction of senescence-associated secretory phenotype (SASP)
  • Rejuvenation effects in aged mouse models (single study)
  • Mechanistically based on FOXO4-p53 binding disruption
  • D-retro-inverso backbone provides enzymatic stability

Epithalon side effects

  • Mild injection site irritation
  • Occasional drowsiness (related to melatonin effects)
  • Rare mild headache
  • Transient changes in sleep patterns

FOX04-DRI side effects

  • Largely uncharacterized in humans
  • Theoretical: off-target apoptosis in non-senescent cells under p53 stress
  • Injection-site reactions
  • Possible effects on stem/progenitor cell populations
  • Acute inflammatory response from senescent-cell debris

Epithalon dosing ranges

Anti-aging and telomere support

5-10 mg · Once daily (SubQ) · 10-20 days, repeated 1-2 times per year

FOX04-DRI dosing ranges

Senolytic research (research-only)

0.4-5 mg/kg · Every other day for 1-2 weeks per cycle · Cycle-based per protocol

Full Epithalon guide → Full FOX04-DRI guide →

Epithalon vs FOX04-DRI — common questions

What is the difference between Epithalon and FOX04-DRI?

Epithalon: Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production. Typical dose 5000-10000 mcg. FOX04-DRI: D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption. Typical dose Per kg dosing (research) mcg. Both fall under the Longevity category.

Can you stack Epithalon and FOX04-DRI?

Stacking Epithalon with FOX04-DRI is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Epithalon or FOX04-DRI?

Epithalon is typically dosed: Once daily (SubQ) for Anti-aging and telomere support. FOX04-DRI is typically dosed: Every other day for 1-2 weeks per cycle for Senolytic research (research-only).

Are Epithalon and FOX04-DRI FDA approved?

Epithalon: Not FDA approved for human use. No clinical trials submitted to the FDA. FOX04-DRI: Not FDA approved. In preclinical / early clinical development as Proxofim (Cleara Biotech).

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