PinnyPeptide

FOX04-DRI vs N-Acetyl Epitalon

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

FOX04-DRI

Longevity

D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption.

Peptide B

N-Acetyl Epitalon

Longevity

Acetylated Epitalon variant — more stable, longer-acting form of the telomerase-activating tetrapeptide.

Typical vial

10 mg

Typical dose

Per kg dosing (research) mcg

Half-life

Extended via DRI backbone (~hours-days)

FDA status

Not FDA approved. In preclinical / early clinical developmen…

Typical vial

5 mg

Typical dose

5,000-10,000 mcg

Half-life

Extended vs. parent Epitalon (acetylation effect)

FDA status

Not FDA approved.

FOX04-DRI effects

  • Selective induction of apoptosis in senescent cells
  • Reduction of senescence-associated secretory phenotype (SASP)
  • Rejuvenation effects in aged mouse models (single study)
  • Mechanistically based on FOXO4-p53 binding disruption
  • D-retro-inverso backbone provides enzymatic stability

N-Acetyl Epitalon effects

  • Telomerase activation in dividing cells (extrapolated from Epitalon)
  • Telomere lengthening reported in long-term Russian studies
  • Modulation of pineal melatonin secretion
  • Reported reduction in age-related mortality in elderly study cohorts
  • Potential immune-modulating effects

FOX04-DRI side effects

  • Largely uncharacterized in humans
  • Theoretical: off-target apoptosis in non-senescent cells under p53 stress
  • Injection-site reactions
  • Possible effects on stem/progenitor cell populations
  • Acute inflammatory response from senescent-cell debris

N-Acetyl Epitalon side effects

  • Generally well-tolerated in Russian studies (parent Epitalon)
  • Mild injection-site reactions
  • Theoretical: telomerase activation in pre-cancerous cells
  • Limited Western safety data

FOX04-DRI dosing ranges

Senolytic research (research-only)

0.4-5 mg/kg · Every other day for 1-2 weeks per cycle · Cycle-based per protocol

N-Acetyl Epitalon dosing ranges

Longevity research

5-10 mg · Once daily · 10-20 day cycles, repeated 2-3 times per year

Full FOX04-DRI guide → Full N-Acetyl Epitalon guide →

FOX04-DRI vs N-Acetyl Epitalon — common questions

What is the difference between FOX04-DRI and N-Acetyl Epitalon?

FOX04-DRI: D-retro-inverso senolytic peptide — selectively kills senescent cells via FOXO4-p53 disruption. Typical dose Per kg dosing (research) mcg. N-Acetyl Epitalon: Acetylated Epitalon variant — more stable, longer-acting form of the telomerase-activating tetrapeptide. Typical dose 5,000-10,000 mcg. Both fall under the Longevity category.

Can you stack FOX04-DRI and N-Acetyl Epitalon?

Stacking FOX04-DRI with N-Acetyl Epitalon is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, FOX04-DRI or N-Acetyl Epitalon?

FOX04-DRI is typically dosed: Every other day for 1-2 weeks per cycle for Senolytic research (research-only). N-Acetyl Epitalon is typically dosed: Once daily for Longevity research.

Are FOX04-DRI and N-Acetyl Epitalon FDA approved?

FOX04-DRI: Not FDA approved. In preclinical / early clinical development as Proxofim (Cleara Biotech). N-Acetyl Epitalon: Not FDA approved.

Related peptide comparisons

epithalon vs fox04-drifox04-dri vs mots-cfox04-dri vs nad-plusfox04-dri vs ss-31epithalon vs n-acetyl-epitalonmots-c vs n-acetyl-epitalon

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