PinnyPeptide

Epithalon vs NAD+ (Injectable)

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Epithalon

Longevity

Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production.

Peptide B

NAD+ (Injectable)

Longevity

Central cellular cofactor — supplemented to support mitochondrial function and sirtuin activity.

Typical vial

10 mg

Typical dose

5000-10000 mcg

Half-life

~30 minutes (short half-life but biological effects persist due to gene expression changes)

FDA status

Not FDA approved for human use. No clinical trials submitted…

Typical vial

500 mg

Typical dose

50-200 mg (SubQ); 500-1500 mg (IV) mcg

Half-life

~6-10 hours (cellular turnover)

FDA status

Not FDA approved as a therapeutic. Available via compounding…

Epithalon effects

  • Activates telomerase enzyme to elongate telomeres
  • Restores melatonin production in the pineal gland
  • Regulates neuroendocrine function and circadian rhythms
  • Reduces incidence of spontaneous tumors in animal models
  • Modulates gene expression patterns associated with aging

NAD+ (Injectable) effects

  • Raises cellular NAD+ levels
  • Supports mitochondrial function via electron transport chain
  • Substrate for sirtuin enzymes (deacetylases linked to longevity)
  • Substrate for PARP enzymes (DNA repair)
  • Substrate for CD38 (immune signaling)
  • Subjective reports of energy, mental clarity, mood

Epithalon side effects

  • Mild injection site irritation
  • Occasional drowsiness (related to melatonin effects)
  • Rare mild headache
  • Transient changes in sleep patterns

NAD+ (Injectable) side effects

  • Flushing during IV infusion (most common, mild)
  • Nausea, chest pressure, abdominal discomfort with rapid infusion
  • Headache
  • Subcutaneous: injection-site irritation
  • Possible methylation depletion with chronic high doses

Epithalon dosing ranges

Anti-aging and telomere support

5-10 mg · Once daily (SubQ) · 10-20 days, repeated 1-2 times per year

NAD+ (Injectable) dosing ranges

IV anti-aging clinic protocol

500-1500 mg · Per infusion, weekly to monthly · Cycle-based

Subcutaneous wellness

50-200 mg · Daily or alternate-day · 2-4 week cycles

Intranasal

20-100 mg · Daily · Cycle-based

Full Epithalon guide → Full NAD+ (Injectable) guide →

Epithalon vs NAD+ (Injectable) — common questions

What is the difference between Epithalon and NAD+ (Injectable)?

Epithalon: Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production. Typical dose 5000-10000 mcg. NAD+ (Injectable): Central cellular cofactor — supplemented to support mitochondrial function and sirtuin activity. Typical dose 50-200 mg (SubQ); 500-1500 mg (IV) mcg. Both fall under the Longevity category.

Can you stack Epithalon and NAD+ (Injectable)?

Stacking Epithalon with NAD+ (Injectable) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Epithalon or NAD+ (Injectable)?

Epithalon is typically dosed: Once daily (SubQ) for Anti-aging and telomere support. NAD+ (Injectable) is typically dosed: Per infusion, weekly to monthly for IV anti-aging clinic protocol; Daily or alternate-day for Subcutaneous wellness; Daily for Intranasal.

Are Epithalon and NAD+ (Injectable) FDA approved?

Epithalon: Not FDA approved for human use. No clinical trials submitted to the FDA. NAD+ (Injectable): Not FDA approved as a therapeutic. Available via compounding pharmacies for off-label use. NAD+ precursors (NR as Niagen, NMN) sold as dietary supplements.

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