PinnyPeptide

Colivelin vs Semax

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Colivelin

Cognitive

Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research.

Peptide B

Semax

Cognitive

Neuroprotective ACTH analog with nootropic and neurotrophic properties.

Typical vial

10 mg

Typical dose

100-500 mcg

Half-life

~hours (longer than parent Humanin)

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

200-600 mcg

Half-life

~2-3 minutes (very rapid degradation; biological effects last hours due to downstream gene expression changes)

FDA status

Not FDA approved for human use. Approved in Russia for strok…

Colivelin effects

  • Femtomolar-range neuroprotection against amyloid-β toxicity
  • Activates STAT3 pro-survival signaling
  • Engages ADNF neurotrophic signaling
  • Attenuates cognitive deficits in Alzheimer's mouse models
  • Activity in ALS and stroke animal models

Semax effects

  • Upregulates BDNF and NGF expression for neuroprotection
  • Enhances memory formation, learning, and attention
  • Promotes neuronal survival after ischemic injury
  • Modulates serotonergic and dopaminergic neurotransmission
  • Supports optic nerve health and visual function

Colivelin side effects

  • Essentially uncharacterized in humans
  • Long-term safety data unavailable
  • Theoretical: off-target STAT3 activation effects
  • Injection-site reactions

Semax side effects

  • Mild nasal irritation with intranasal administration
  • Occasional headache
  • Rare anecdotal reports of hair thinning at high doses
  • Mild dizziness in sensitive individuals

Colivelin dosing ranges

Neuroprotection research (intranasal)

100-500 mcg · Once daily · Per research protocol

Subcutaneous research

100-500 mcg · Once daily · Per research protocol

Semax dosing ranges

Cognitive enhancement

200-600 mcg · Once or twice daily (intranasal) · 10-20 days per course

Neuroprotection / stroke recovery

600-1200 mcg · Two to three times daily (intranasal) · 10-14 days

Full Colivelin guide → Full Semax guide →

Colivelin vs Semax — common questions

What is the difference between Colivelin and Semax?

Colivelin: Hybrid Humanin / ADNF peptide — high-potency neuroprotective agent for Alzheimer's research. Typical dose 100-500 mcg. Semax: Neuroprotective ACTH analog with nootropic and neurotrophic properties. Typical dose 200-600 mcg. Both fall under the Cognitive category.

Can you stack Colivelin and Semax?

Stacking Colivelin with Semax is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Colivelin or Semax?

Colivelin is typically dosed: Once daily for Neuroprotection research (intranasal); Once daily for Subcutaneous research. Semax is typically dosed: Once or twice daily (intranasal) for Cognitive enhancement; Two to three times daily (intranasal) for Neuroprotection / stroke recovery.

Are Colivelin and Semax FDA approved?

Colivelin: Not FDA approved. Semax: Not FDA approved for human use. Approved in Russia for stroke recovery, cognitive impairment, and optic nerve disease.

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