Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Immune
Thymic peptide with broad immunomodulatory activity, approved in over 35 countries.
Peptide B
Healing & Recovery
Broad neuropeptide with anti-inflammatory, immunomodulatory, and vasodilatory activity.
Typical vial
5 mg
Typical dose
1000-1600 mcg
Half-life
~2 hours
FDA status
Not FDA approved. Granted orphan drug designation for hepato…
Typical vial
5 mg
Typical dose
50-200 (intranasal) mcg
Half-life
~2 minutes (plasma); longer functional duration via tissue distribution
FDA status
Not FDA approved as therapeutic. VIP analog aviptadil receiv…
Thymosin Alpha-1 effects
VIP (Vasoactive Intestinal Peptide) effects
Thymosin Alpha-1 side effects
VIP (Vasoactive Intestinal Peptide) side effects
Thymosin Alpha-1 dosing ranges
Immune modulation
1000-1600 mcg · Twice weekly (SubQ) · 6-12 months
Hepatitis treatment (clinical protocol)
1600 mcg · Twice weekly · 6-12 months
Acute immune support
1600 mcg · Daily for initial phase, then twice weekly · 2-4 weeks acute, then maintenance
VIP (Vasoactive Intestinal Peptide) dosing ranges
Intranasal CIRS protocol (off-label)
50 mcg · 4 sprays daily · Per Shoemaker protocol; months to years for full restoration
Research / immunomodulation
Variable per protocol · Per protocol · Per protocol
Thymosin Alpha-1: Thymic peptide with broad immunomodulatory activity, approved in over 35 countries. Typical dose 1000-1600 mcg. VIP (Vasoactive Intestinal Peptide): Broad neuropeptide with anti-inflammatory, immunomodulatory, and vasodilatory activity. Typical dose 50-200 (intranasal) mcg. Both fall under the Immune and Healing & Recovery categories.
Stacking Thymosin Alpha-1 with VIP (Vasoactive Intestinal Peptide) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
Thymosin Alpha-1 is typically dosed: Twice weekly (SubQ) for Immune modulation; Twice weekly for Hepatitis treatment (clinical protocol); Daily for initial phase, then twice weekly for Acute immune support. VIP (Vasoactive Intestinal Peptide) is typically dosed: 4 sprays daily for Intranasal CIRS protocol (off-label); Per protocol for Research / immunomodulation.
Thymosin Alpha-1: Not FDA approved. Granted orphan drug designation for hepatocellular carcinoma and hepatitis B. Multiple clinical trials conducted but no NDA submitted. VIP (Vasoactive Intestinal Peptide): Not FDA approved as therapeutic. VIP analog aviptadil received Emergency Use Authorization consideration for COVID-19 ARDS but not full approval.
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