PinnyPeptide

PE22-28 vs Selank

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

PE22-28

Cognitive

Fast-acting antidepressant peptide acting via TREK-1 channel inhibition.

Peptide B

Selank

Cognitive

Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties.

Typical vial

5 mg

Typical dose

50-200 mcg

Half-life

Hours; precise value species-dependent

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~15-30 minutes (extended biological effect due to downstream signaling)

FDA status

Not FDA approved for human use.

PE22-28 effects

  • Selective TREK-1 potassium channel inhibition
  • Fast-onset antidepressant-like effects in rodent models
  • Increased serotonergic neuron firing in dorsal raphe
  • Enhanced BDNF / TrkB signaling downstream
  • Anti-anxiety effects in some assays

Selank effects

  • Reduces anxiety without sedation or cognitive impairment
  • Enhances memory consolidation and learning
  • Modulates serotonin, dopamine, and GABA neurotransmitter systems
  • Provides immunomodulatory effects through cytokine balance regulation
  • Increases brain-derived neurotrophic factor (BDNF) expression

PE22-28 side effects

  • Essentially uncharacterized in humans
  • Theoretical: TREK-1 inhibition off-target in heart, immune cells
  • Subjective reports of mood activation, occasional anxiety
  • Injection-site reactions
  • Sleep disturbance with late-day dosing

Selank side effects

  • Mild nasal irritation (intranasal administration)
  • Fatigue during initial use (transient)
  • Occasional lightheadedness

PE22-28 dosing ranges

Antidepressant research (preclinical)

100-500 mcg/kg · Daily SubQ or IP · Per protocol

Self-experimentation (no clinical guidance)

50-200 mcg · Once or twice daily · 2-4 weeks per cycle

Selank dosing ranges

Anxiolytic and cognitive enhancement (intranasal)

250-500 mcg · Two to three times daily · 2-4 weeks

Subcutaneous injection

250-500 mcg · Once daily · 2-4 weeks

Full PE22-28 guide → Full Selank guide →

PE22-28 vs Selank — common questions

What is the difference between PE22-28 and Selank?

PE22-28: Fast-acting antidepressant peptide acting via TREK-1 channel inhibition. Typical dose 50-200 mcg. Selank: Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties. Typical dose 250-500 mcg. Both fall under the Cognitive category.

Can you stack PE22-28 and Selank?

Stacking PE22-28 with Selank is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, PE22-28 or Selank?

PE22-28 is typically dosed: Daily SubQ or IP for Antidepressant research (preclinical); Once or twice daily for Self-experimentation (no clinical guidance). Selank is typically dosed: Two to three times daily for Anxiolytic and cognitive enhancement (intranasal); Once daily for Subcutaneous injection.

Are PE22-28 and Selank FDA approved?

PE22-28: Not FDA approved. Selank: Not FDA approved for human use.

Related peptide comparisons

adamax vs pe22-28colivelin vs pe22-28dihexa vs pe22-28dnsp-11 vs pe22-28p21 vs pe22-28pe22-28 vs pinealon

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