Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Cognitive
Eleven-amino-acid peptide derived from the GDNF prodomain — neuroprotective for dopamine neurons.
Peptide B
Cognitive
Fast-acting antidepressant peptide acting via TREK-1 channel inhibition.
Typical vial
5 mg
Typical dose
Variable (research-specific) mcg
Half-life
Short; precise value uncharacterized
FDA status
Not FDA approved.
Typical vial
5 mg
Typical dose
50-200 mcg
Half-life
Hours; precise value species-dependent
FDA status
Not FDA approved.
DNSP-11 effects
PE22-28 effects
DNSP-11 side effects
PE22-28 side effects
DNSP-11 dosing ranges
Research / Parkinson's models (preclinical)
Variable per protocol · ICV or peripheral routes · Per research design
PE22-28 dosing ranges
Antidepressant research (preclinical)
100-500 mcg/kg · Daily SubQ or IP · Per protocol
Self-experimentation (no clinical guidance)
50-200 mcg · Once or twice daily · 2-4 weeks per cycle
DNSP-11: Eleven-amino-acid peptide derived from the GDNF prodomain — neuroprotective for dopamine neurons. Typical dose Variable (research-specific) mcg. PE22-28: Fast-acting antidepressant peptide acting via TREK-1 channel inhibition. Typical dose 50-200 mcg. Both fall under the Cognitive category.
Stacking DNSP-11 with PE22-28 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
DNSP-11 is typically dosed: ICV or peripheral routes for Research / Parkinson's models (preclinical). PE22-28 is typically dosed: Daily SubQ or IP for Antidepressant research (preclinical); Once or twice daily for Self-experimentation (no clinical guidance).
DNSP-11: Not FDA approved. PE22-28: Not FDA approved.
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