Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Growth Hormone
The most potent GHRP — strong GH release with documented cardioprotective signaling.
Peptide B
Growth Hormone
The original GHRH analog and the first FDA-approved peptide secretagogue.
Typical vial
5 mg
Typical dose
100 mcg
Half-life
~55 minutes
FDA status
Not FDA approved for any indication.
Typical vial
5 mg
Typical dose
200-500 mcg
Half-life
~12 minutes
FDA status
Previously FDA approved (1997, as Geref) for pediatric GHD. …
Hexarelin effects
Sermorelin effects
Hexarelin side effects
Sermorelin side effects
Hexarelin dosing ranges
Short-course GH stimulation
100 mcg · Two to three times daily (SubQ) · 4 weeks maximum, then 4-week break
Combined with CJC-1295 (Mod GRF)
100 mcg of each · Two to three times daily · 4 weeks on / 4 weeks off
Cardioprotective research
1-2 mcg/kg · Per protocol (research-only) · Variable
Sermorelin dosing ranges
GH optimization / anti-aging
200-500 mcg · Once daily before bed (SubQ) · 3-6 months, then reassess
Combined with Ipamorelin
200-300 mcg of each · Once daily before bed · 3-6 months
Pediatric GHD (historical, prescribing-physician only)
30 mcg/kg · Once daily before bed · Per endocrinologist
Hexarelin: The most potent GHRP — strong GH release with documented cardioprotective signaling. Typical dose 100 mcg. Sermorelin: The original GHRH analog and the first FDA-approved peptide secretagogue. Typical dose 200-500 mcg. Both fall under the Growth Hormone category.
Stacking Hexarelin with Sermorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
Hexarelin is typically dosed: Two to three times daily (SubQ) for Short-course GH stimulation; Two to three times daily for Combined with CJC-1295 (Mod GRF); Per protocol (research-only) for Cardioprotective research. Sermorelin is typically dosed: Once daily before bed (SubQ) for GH optimization / anti-aging; Once daily before bed for Combined with Ipamorelin; Once daily before bed for Pediatric GHD (historical, prescribing-physician only).
Hexarelin: Not FDA approved for any indication. Sermorelin: Previously FDA approved (1997, as Geref) for pediatric GHD. Brand discontinued 2008. Available in the US via compounding pharmacies on prescription.
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