PinnyPeptide

CJC-1295 vs Sermorelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

CJC-1295

Growth Hormone

Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation.

Peptide B

Sermorelin

Growth Hormone

The original GHRH analog and the first FDA-approved peptide secretagogue.

Typical vial

2 mg

Typical dose

100-300 mcg

Half-life

~30 minutes (no DAC) / 6-8 days (with DAC)

FDA status

Not FDA approved for human use.

Typical vial

5 mg

Typical dose

200-500 mcg

Half-life

~12 minutes

FDA status

Previously FDA approved (1997, as Geref) for pediatric GHD. …

CJC-1295 effects

  • Increases growth hormone secretion from the pituitary
  • Elevates IGF-1 levels for sustained anabolic signaling
  • Promotes fat metabolism and improved body composition
  • Supports deeper, more restorative sleep patterns
  • Enhances recovery from exercise and tissue repair

Sermorelin effects

  • Stimulates endogenous growth hormone release via the pituitary
  • Increases IGF-1 within physiological range
  • Improves sleep depth, particularly slow-wave sleep
  • Supports lean body mass and fat metabolism
  • Preserves the natural pulsatile rhythm of GH secretion

CJC-1295 side effects

  • Injection site redness, swelling, or irritation
  • Water retention and bloating
  • Tingling or numbness in the extremities
  • Headache
  • Dizziness or flushing shortly after injection

Sermorelin side effects

  • Injection site redness or itching
  • Mild flushing immediately after injection
  • Headache (uncommon, usually transient)
  • Dizziness or sleepiness
  • Rare elevation of liver enzymes with chronic use

CJC-1295 dosing ranges

Anti-aging and recovery (Mod GRF)

100 mcg · Once to three times daily (SubQ) · 8-12 weeks

Body composition (Mod GRF + Ipamorelin)

100-300 mcg · Two to three times daily · 8-12 weeks

CJC-1295 with DAC

1000-2000 mcg · Once or twice weekly · 8-12 weeks

Sermorelin dosing ranges

GH optimization / anti-aging

200-500 mcg · Once daily before bed (SubQ) · 3-6 months, then reassess

Combined with Ipamorelin

200-300 mcg of each · Once daily before bed · 3-6 months

Pediatric GHD (historical, prescribing-physician only)

30 mcg/kg · Once daily before bed · Per endocrinologist

CJC-1295 vs Sermorelin — common questions

What is the difference between CJC-1295 and Sermorelin?

CJC-1295: Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation. Typical dose 100-300 mcg. Sermorelin: The original GHRH analog and the first FDA-approved peptide secretagogue. Typical dose 200-500 mcg. Both fall under the Growth Hormone category.

Can you stack CJC-1295 and Sermorelin?

Stacking CJC-1295 with Sermorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, CJC-1295 or Sermorelin?

CJC-1295 is typically dosed: Once to three times daily (SubQ) for Anti-aging and recovery (Mod GRF); Two to three times daily for Body composition (Mod GRF + Ipamorelin); Once or twice weekly for CJC-1295 with DAC. Sermorelin is typically dosed: Once daily before bed (SubQ) for GH optimization / anti-aging; Once daily before bed for Combined with Ipamorelin; Once daily before bed for Pediatric GHD (historical, prescribing-physician only).

Are CJC-1295 and Sermorelin FDA approved?

CJC-1295: Not FDA approved for human use. Sermorelin: Previously FDA approved (1997, as Geref) for pediatric GHD. Brand discontinued 2008. Available in the US via compounding pharmacies on prescription.

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free