PinnyPeptide

CJC-1295 vs HGH Fragment 176-191

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

CJC-1295

Growth Hormone

Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation.

Peptide B

HGH Fragment 176-191

Weight Management

The unmodified C-terminal fragment of growth hormone — the original lipolytic peptide.

Typical vial

2 mg

Typical dose

100-300 mcg

Half-life

~30 minutes (no DAC) / 6-8 days (with DAC)

FDA status

Not FDA approved for human use.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~30 minutes

FDA status

Not FDA approved. Distinct from AOD-9604, which holds GRAS s…

CJC-1295 effects

  • Increases growth hormone secretion from the pituitary
  • Elevates IGF-1 levels for sustained anabolic signaling
  • Promotes fat metabolism and improved body composition
  • Supports deeper, more restorative sleep patterns
  • Enhances recovery from exercise and tissue repair

HGH Fragment 176-191 effects

  • Stimulates lipolysis (fat breakdown) in adipose tissue
  • Inhibits lipogenesis (new fat formation)
  • Does not bind the GH receptor
  • Does not raise IGF-1 or affect blood glucose
  • Targets stubborn / subcutaneous fat in cut-phase protocols

CJC-1295 side effects

  • Injection site redness, swelling, or irritation
  • Water retention and bloating
  • Tingling or numbness in the extremities
  • Headache
  • Dizziness or flushing shortly after injection

HGH Fragment 176-191 side effects

  • Injection-site irritation or redness
  • Occasional headache
  • Mild fatigue at the start of a cycle (rare)
  • Transient flushing

CJC-1295 dosing ranges

Anti-aging and recovery (Mod GRF)

100 mcg · Once to three times daily (SubQ) · 8-12 weeks

Body composition (Mod GRF + Ipamorelin)

100-300 mcg · Two to three times daily · 8-12 weeks

CJC-1295 with DAC

1000-2000 mcg · Once or twice weekly · 8-12 weeks

HGH Fragment 176-191 dosing ranges

Fat loss / body recomposition

250-500 mcg · Once daily, morning, on an empty stomach (SubQ) · 8-12 weeks

Split-dose protocol for stubborn fat

250 mcg · Twice daily (morning + pre-cardio), fasted · 8-12 weeks

CJC-1295 vs HGH Fragment 176-191 — common questions

What is the difference between CJC-1295 and HGH Fragment 176-191?

CJC-1295: Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation. Typical dose 100-300 mcg. HGH Fragment 176-191: The unmodified C-terminal fragment of growth hormone — the original lipolytic peptide. Typical dose 250-500 mcg. Both fall under the Growth Hormone and Weight Management categories.

Can you stack CJC-1295 and HGH Fragment 176-191?

Stacking CJC-1295 with HGH Fragment 176-191 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, CJC-1295 or HGH Fragment 176-191?

CJC-1295 is typically dosed: Once to three times daily (SubQ) for Anti-aging and recovery (Mod GRF); Two to three times daily for Body composition (Mod GRF + Ipamorelin); Once or twice weekly for CJC-1295 with DAC. HGH Fragment 176-191 is typically dosed: Once daily, morning, on an empty stomach (SubQ) for Fat loss / body recomposition; Twice daily (morning + pre-cardio), fasted for Split-dose protocol for stubborn fat.

Are CJC-1295 and HGH Fragment 176-191 FDA approved?

CJC-1295: Not FDA approved for human use. HGH Fragment 176-191: Not FDA approved. Distinct from AOD-9604, which holds GRAS status as a food additive.

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