PinnyPeptide

CJC-1295 vs IGF-1 LR3

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

CJC-1295

Growth Hormone

Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation.

Peptide B

IGF-1 LR3

Muscle Growth

Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling.

Typical vial

2 mg

Typical dose

100-300 mcg

Half-life

~30 minutes (no DAC) / 6-8 days (with DAC)

FDA status

Not FDA approved for human use.

Typical vial

1 mg

Typical dose

20-50 mcg

Half-life

~20-30 hours

FDA status

Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Inc…

CJC-1295 effects

  • Increases growth hormone secretion from the pituitary
  • Elevates IGF-1 levels for sustained anabolic signaling
  • Promotes fat metabolism and improved body composition
  • Supports deeper, more restorative sleep patterns
  • Enhances recovery from exercise and tissue repair

IGF-1 LR3 effects

  • Sustained IGF-1 receptor activation (20-30 hour half-life)
  • Muscle cell hyperplasia (increased cell number, not just size)
  • Anabolic signaling via PI3K-Akt-mTOR pathway
  • Improved nutrient partitioning toward muscle
  • Enhanced recovery from training-induced damage

CJC-1295 side effects

  • Injection site redness, swelling, or irritation
  • Water retention and bloating
  • Tingling or numbness in the extremities
  • Headache
  • Dizziness or flushing shortly after injection

IGF-1 LR3 side effects

  • Hypoglycemia (real risk — IGF-1 has insulin-like activity)
  • Joint pain and stiffness
  • Carpal tunnel-like symptoms
  • Lethargy / lightheadedness from glucose drops
  • Possible tumor-promoting effects (theoretical, dose-dependent)
  • Localized lipohypertrophy or muscle asymmetry with site injection

CJC-1295 dosing ranges

Anti-aging and recovery (Mod GRF)

100 mcg · Once to three times daily (SubQ) · 8-12 weeks

Body composition (Mod GRF + Ipamorelin)

100-300 mcg · Two to three times daily · 8-12 weeks

CJC-1295 with DAC

1000-2000 mcg · Once or twice weekly · 8-12 weeks

IGF-1 LR3 dosing ranges

Research / muscle hypertrophy

20-50 mcg · Once daily (SubQ or IM), pre- or post-workout · 30-50 days per cycle

Site-specific injection (research)

20-40 mcg per site · Into trained muscle, post-workout · 30-50 days per cycle

CJC-1295 vs IGF-1 LR3 — common questions

What is the difference between CJC-1295 and IGF-1 LR3?

CJC-1295: Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation. Typical dose 100-300 mcg. IGF-1 LR3: Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling. Typical dose 20-50 mcg. Both fall under the Growth Hormone and Muscle Growth categories.

Can you stack CJC-1295 and IGF-1 LR3?

Stacking CJC-1295 with IGF-1 LR3 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, CJC-1295 or IGF-1 LR3?

CJC-1295 is typically dosed: Once to three times daily (SubQ) for Anti-aging and recovery (Mod GRF); Two to three times daily for Body composition (Mod GRF + Ipamorelin); Once or twice weekly for CJC-1295 with DAC. IGF-1 LR3 is typically dosed: Once daily (SubQ or IM), pre- or post-workout for Research / muscle hypertrophy; Into trained muscle, post-workout for Site-specific injection (research).

Are CJC-1295 and IGF-1 LR3 FDA approved?

CJC-1295: Not FDA approved for human use. IGF-1 LR3: Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Increlex) is FDA approved for severe primary IGF-1 deficiency in children, but IGF-1 LR3 itself is not.

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