PinnyPeptide

DNSP-11 vs Selank

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

DNSP-11

Cognitive

Eleven-amino-acid peptide derived from the GDNF prodomain — neuroprotective for dopamine neurons.

Peptide B

Selank

Cognitive

Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties.

Typical vial

5 mg

Typical dose

Variable (research-specific) mcg

Half-life

Short; precise value uncharacterized

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~15-30 minutes (extended biological effect due to downstream signaling)

FDA status

Not FDA approved for human use.

DNSP-11 effects

  • Dopaminergic neuroprotection in Parkinson's models
  • Increased dopamine production in dopaminergic neurons
  • Improved motor function in 6-OHDA and MPTP models
  • Mechanism distinct from full-length GDNF
  • Investigational for Parkinson's and related disorders

Selank effects

  • Reduces anxiety without sedation or cognitive impairment
  • Enhances memory consolidation and learning
  • Modulates serotonin, dopamine, and GABA neurotransmitter systems
  • Provides immunomodulatory effects through cytokine balance regulation
  • Increases brain-derived neurotrophic factor (BDNF) expression

DNSP-11 side effects

  • Essentially uncharacterized in humans
  • Possible local tissue effects with intracerebroventricular delivery
  • Theoretical: off-target effects on non-dopaminergic neurons
  • Injection-site reactions

Selank side effects

  • Mild nasal irritation (intranasal administration)
  • Fatigue during initial use (transient)
  • Occasional lightheadedness

DNSP-11 dosing ranges

Research / Parkinson's models (preclinical)

Variable per protocol · ICV or peripheral routes · Per research design

Selank dosing ranges

Anxiolytic and cognitive enhancement (intranasal)

250-500 mcg · Two to three times daily · 2-4 weeks

Subcutaneous injection

250-500 mcg · Once daily · 2-4 weeks

Full DNSP-11 guide → Full Selank guide →

DNSP-11 vs Selank — common questions

What is the difference between DNSP-11 and Selank?

DNSP-11: Eleven-amino-acid peptide derived from the GDNF prodomain — neuroprotective for dopamine neurons. Typical dose Variable (research-specific) mcg. Selank: Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties. Typical dose 250-500 mcg. Both fall under the Cognitive category.

Can you stack DNSP-11 and Selank?

Stacking DNSP-11 with Selank is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, DNSP-11 or Selank?

DNSP-11 is typically dosed: ICV or peripheral routes for Research / Parkinson's models (preclinical). Selank is typically dosed: Two to three times daily for Anxiolytic and cognitive enhancement (intranasal); Once daily for Subcutaneous injection.

Are DNSP-11 and Selank FDA approved?

DNSP-11: Not FDA approved. Selank: Not FDA approved for human use.

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