PinnyPeptide

Dihexa vs Selank

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Dihexa

Cognitive

Hepatocyte growth factor mimetic — claimed to be 7 orders of magnitude more potent than BDNF.

Peptide B

Selank

Cognitive

Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties.

Typical vial

30 mg

Typical dose

8,000-45,000 (oral) mcg

Half-life

~3-4 hours (oral)

FDA status

Not FDA approved. The related HGF-positive modulator fosgoni…

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~15-30 minutes (extended biological effect due to downstream signaling)

FDA status

Not FDA approved for human use.

Dihexa effects

  • Claimed promotion of dendritic spine formation
  • HGF / c-Met signaling enhancement
  • Procognitive effects in rodent models
  • Orally bioavailable (rare for peptides)
  • Anecdotal cognitive enhancement in human users

Selank effects

  • Reduces anxiety without sedation or cognitive impairment
  • Enhances memory consolidation and learning
  • Modulates serotonin, dopamine, and GABA neurotransmitter systems
  • Provides immunomodulatory effects through cytokine balance regulation
  • Increases brain-derived neurotrophic factor (BDNF) expression

Dihexa side effects

  • Essentially uncharacterized in humans
  • Headache (commonly reported in self-experimentation)
  • Increased emotionality / mood changes (subjective reports)
  • Theoretical: pro-oncogenic concerns via HGF / c-Met activation
  • Insomnia with late-day dosing

Selank side effects

  • Mild nasal irritation (intranasal administration)
  • Fatigue during initial use (transient)
  • Occasional lightheadedness

Dihexa dosing ranges

Cognitive research (oral / sublingual)

8-45 mg · Once daily · 30 days per cycle

Selank dosing ranges

Anxiolytic and cognitive enhancement (intranasal)

250-500 mcg · Two to three times daily · 2-4 weeks

Subcutaneous injection

250-500 mcg · Once daily · 2-4 weeks

Full Dihexa guide → Full Selank guide →

Dihexa vs Selank — common questions

What is the difference between Dihexa and Selank?

Dihexa: Hepatocyte growth factor mimetic — claimed to be 7 orders of magnitude more potent than BDNF. Typical dose 8,000-45,000 (oral) mcg. Selank: Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties. Typical dose 250-500 mcg. Both fall under the Cognitive category.

Can you stack Dihexa and Selank?

Stacking Dihexa with Selank is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Dihexa or Selank?

Dihexa is typically dosed: Once daily for Cognitive research (oral / sublingual). Selank is typically dosed: Two to three times daily for Anxiolytic and cognitive enhancement (intranasal); Once daily for Subcutaneous injection.

Are Dihexa and Selank FDA approved?

Dihexa: Not FDA approved. The related HGF-positive modulator fosgonimeton (ATH-1017) is in clinical trials for Alzheimer's. Selank: Not FDA approved for human use.

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