PinnyPeptide

Crystagen vs Thymalin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Crystagen

Bioregulators

Khavinson short peptide bioregulator targeting thymus / immune cells.

Peptide B

Thymalin

Bioregulators

Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

10 mg

Typical dose

5,000-30,000 mcg

Half-life

Variable (peptide complex)

FDA status

Not FDA approved.

Crystagen effects

  • Reported improvement in T-cell numbers and function
  • Restoration of age-related immune decline (Russian observational)
  • Support of thymic function in elderly patients
  • Anti-inflammatory effects
  • Recovery support after severe illness

Thymalin effects

  • Reported improvement in T-cell numbers (especially CD4+)
  • Improvement in CD4/CD8 ratio
  • Enhanced NK-cell function
  • Reduction in infection rates in immunocompromised patients
  • Long-term observational reduction in mortality (Khavinson 2003 study)
  • Anti-inflammatory effects

Crystagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Theoretical: caution in active autoimmune disease (immune modulation)

Thymalin side effects

  • Generally well-tolerated across 40 years of Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Caution in active autoimmune disease

Crystagen dosing ranges

Immune support

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Thymalin dosing ranges

Immune support (Russian clinical)

5-30 mg · Once daily IM or SubQ · 5-10 day course, repeated 2-3 times per year

Full Crystagen guide → Full Thymalin guide →

Crystagen vs Thymalin — common questions

What is the difference between Crystagen and Thymalin?

Crystagen: Khavinson short peptide bioregulator targeting thymus / immune cells. Typical dose 1,000-5,000 mcg. Thymalin: Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record. Typical dose 5,000-30,000 mcg. Both fall under the Bioregulators category.

Can you stack Crystagen and Thymalin?

Stacking Crystagen with Thymalin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Crystagen or Thymalin?

Crystagen is typically dosed: Once daily (SubQ) or sublingual for Immune support. Thymalin is typically dosed: Once daily IM or SubQ for Immune support (Russian clinical).

Are Crystagen and Thymalin FDA approved?

Crystagen: Not FDA approved. Thymalin: Not FDA approved.

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