PinnyPeptide

Cortagen vs Crystagen

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Cortagen

Bioregulators

Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression.

Peptide B

Crystagen

Bioregulators

Khavinson short peptide bioregulator targeting thymus / immune cells.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Cortagen effects

  • Reported support of cortical neuron function and gene expression
  • Improvements in memory and attention (Russian observational)
  • Neuroprotection in cerebral ischemia models
  • Possible support for post-stroke and post-concussive recovery
  • Modulation of neuroplasticity-related gene expression

Crystagen effects

  • Reported improvement in T-cell numbers and function
  • Restoration of age-related immune decline (Russian observational)
  • Support of thymic function in elderly patients
  • Anti-inflammatory effects
  • Recovery support after severe illness

Cortagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Possible mild sleep disturbance with late-day dosing

Crystagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Theoretical: caution in active autoimmune disease (immune modulation)

Cortagen dosing ranges

Cognitive support

1-5 mg · Once daily morning (SubQ) or intranasal · 10-20 day cycles, repeated 2-3 times per year

Crystagen dosing ranges

Immune support

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Full Cortagen guide → Full Crystagen guide →

Cortagen vs Crystagen — common questions

What is the difference between Cortagen and Crystagen?

Cortagen: Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression. Typical dose 1,000-5,000 mcg. Crystagen: Khavinson short peptide bioregulator targeting thymus / immune cells. Typical dose 1,000-5,000 mcg. Both fall under the Bioregulators category.

Can you stack Cortagen and Crystagen?

Stacking Cortagen with Crystagen is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Cortagen or Crystagen?

Cortagen is typically dosed: Once daily morning (SubQ) or intranasal for Cognitive support. Crystagen is typically dosed: Once daily (SubQ) or sublingual for Immune support.

Are Cortagen and Crystagen FDA approved?

Cortagen: Not FDA approved. Crystagen: Not FDA approved.

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