PinnyPeptide

Cortagen vs Vesugen

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Cortagen

Bioregulators

Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression.

Peptide B

Vesugen

Bioregulators

Khavinson short peptide bioregulator targeting vascular endothelium — KED tripeptide.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Cortagen effects

  • Reported support of cortical neuron function and gene expression
  • Improvements in memory and attention (Russian observational)
  • Neuroprotection in cerebral ischemia models
  • Possible support for post-stroke and post-concussive recovery
  • Modulation of neuroplasticity-related gene expression

Vesugen effects

  • Reported improvement in endothelial function (flow-mediated dilation)
  • Reduction in arterial stiffness measures
  • Anti-inflammatory effects on vascular endothelium
  • Modulation of vascular gene expression
  • Support of nitric oxide synthesis

Cortagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Possible mild sleep disturbance with late-day dosing

Vesugen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Should not substitute for proven cardiovascular therapies

Cortagen dosing ranges

Cognitive support

1-5 mg · Once daily morning (SubQ) or intranasal · 10-20 day cycles, repeated 2-3 times per year

Vesugen dosing ranges

Vascular health support

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Full Cortagen guide → Full Vesugen guide →

Cortagen vs Vesugen — common questions

What is the difference between Cortagen and Vesugen?

Cortagen: Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression. Typical dose 1,000-5,000 mcg. Vesugen: Khavinson short peptide bioregulator targeting vascular endothelium — KED tripeptide. Typical dose 1,000-5,000 mcg. Both fall under the Bioregulators category.

Can you stack Cortagen and Vesugen?

Stacking Cortagen with Vesugen is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Cortagen or Vesugen?

Cortagen is typically dosed: Once daily morning (SubQ) or intranasal for Cognitive support. Vesugen is typically dosed: Once daily (SubQ) or sublingual for Vascular health support.

Are Cortagen and Vesugen FDA approved?

Cortagen: Not FDA approved. Vesugen: Not FDA approved.

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