PinnyPeptide

Cortagen vs Thymalin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Cortagen

Bioregulators

Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression.

Peptide B

Thymalin

Bioregulators

Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

10 mg

Typical dose

5,000-30,000 mcg

Half-life

Variable (peptide complex)

FDA status

Not FDA approved.

Cortagen effects

  • Reported support of cortical neuron function and gene expression
  • Improvements in memory and attention (Russian observational)
  • Neuroprotection in cerebral ischemia models
  • Possible support for post-stroke and post-concussive recovery
  • Modulation of neuroplasticity-related gene expression

Thymalin effects

  • Reported improvement in T-cell numbers (especially CD4+)
  • Improvement in CD4/CD8 ratio
  • Enhanced NK-cell function
  • Reduction in infection rates in immunocompromised patients
  • Long-term observational reduction in mortality (Khavinson 2003 study)
  • Anti-inflammatory effects

Cortagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Possible mild sleep disturbance with late-day dosing

Thymalin side effects

  • Generally well-tolerated across 40 years of Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Caution in active autoimmune disease

Cortagen dosing ranges

Cognitive support

1-5 mg · Once daily morning (SubQ) or intranasal · 10-20 day cycles, repeated 2-3 times per year

Thymalin dosing ranges

Immune support (Russian clinical)

5-30 mg · Once daily IM or SubQ · 5-10 day course, repeated 2-3 times per year

Full Cortagen guide → Full Thymalin guide →

Cortagen vs Thymalin — common questions

What is the difference between Cortagen and Thymalin?

Cortagen: Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression. Typical dose 1,000-5,000 mcg. Thymalin: Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record. Typical dose 5,000-30,000 mcg. Both fall under the Bioregulators category.

Can you stack Cortagen and Thymalin?

Stacking Cortagen with Thymalin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Cortagen or Thymalin?

Cortagen is typically dosed: Once daily morning (SubQ) or intranasal for Cognitive support. Thymalin is typically dosed: Once daily IM or SubQ for Immune support (Russian clinical).

Are Cortagen and Thymalin FDA approved?

Cortagen: Not FDA approved. Thymalin: Not FDA approved.

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