PinnyPeptide

Cortagen vs Pancragen

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Cortagen

Bioregulators

Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression.

Peptide B

Pancragen

Bioregulators

Khavinson short peptide bioregulator targeting pancreatic tissue and glucose metabolism.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Cortagen effects

  • Reported support of cortical neuron function and gene expression
  • Improvements in memory and attention (Russian observational)
  • Neuroprotection in cerebral ischemia models
  • Possible support for post-stroke and post-concussive recovery
  • Modulation of neuroplasticity-related gene expression

Pancragen effects

  • Reported support of residual β-cell function
  • Improvements in fasting glucose and HbA1c (Russian observational)
  • Support of exocrine pancreatic function
  • Improvement in digestion in pancreatic insufficiency
  • Modulation of pancreatic gene expression

Cortagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Possible mild sleep disturbance with late-day dosing

Pancragen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Should not substitute for proven diabetes therapies

Cortagen dosing ranges

Cognitive support

1-5 mg · Once daily morning (SubQ) or intranasal · 10-20 day cycles, repeated 2-3 times per year

Pancragen dosing ranges

Pancreatic support

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Full Cortagen guide → Full Pancragen guide →

Cortagen vs Pancragen — common questions

What is the difference between Cortagen and Pancragen?

Cortagen: Khavinson short peptide bioregulator targeting cortical neurons and CNS gene expression. Typical dose 1,000-5,000 mcg. Pancragen: Khavinson short peptide bioregulator targeting pancreatic tissue and glucose metabolism. Typical dose 1,000-5,000 mcg. Both fall under the Bioregulators category.

Can you stack Cortagen and Pancragen?

Stacking Cortagen with Pancragen is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Cortagen or Pancragen?

Cortagen is typically dosed: Once daily morning (SubQ) or intranasal for Cognitive support. Pancragen is typically dosed: Once daily (SubQ) or sublingual for Pancreatic support.

Are Cortagen and Pancragen FDA approved?

Cortagen: Not FDA approved. Pancragen: Not FDA approved.

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