PinnyPeptide

CJC-1295 vs Tesamorelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

CJC-1295

Growth Hormone

Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation.

Peptide B

Tesamorelin

Growth Hormone

FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity.

Typical vial

2 mg

Typical dose

100-300 mcg

Half-life

~30 minutes (no DAC) / 6-8 days (with DAC)

FDA status

Not FDA approved for human use.

Typical vial

2 mg

Typical dose

1000-2000 mcg

Half-life

~26 minutes

FDA status

FDA approved. Egrifta (tesamorelin) approved November 2010 f…

CJC-1295 effects

  • Increases growth hormone secretion from the pituitary
  • Elevates IGF-1 levels for sustained anabolic signaling
  • Promotes fat metabolism and improved body composition
  • Supports deeper, more restorative sleep patterns
  • Enhances recovery from exercise and tissue repair

Tesamorelin effects

  • FDA-proven reduction of visceral adipose tissue
  • Stimulates physiological pulsatile GH release
  • Improves body composition by reducing trunk fat
  • May enhance cognitive function in older adults
  • Increases IGF-1 levels
  • Does not significantly affect glucose homeostasis at approved doses

CJC-1295 side effects

  • Injection site redness, swelling, or irritation
  • Water retention and bloating
  • Tingling or numbness in the extremities
  • Headache
  • Dizziness or flushing shortly after injection

Tesamorelin side effects

  • Injection site reactions (erythema, pruritus, pain)
  • Arthralgia (joint pain)
  • Peripheral edema
  • Myalgia (muscle pain)
  • Hypersensitivity reactions (rare)
  • Potential increase in IGF-1 above normal range

CJC-1295 dosing ranges

Anti-aging and recovery (Mod GRF)

100 mcg · Once to three times daily (SubQ) · 8-12 weeks

Body composition (Mod GRF + Ipamorelin)

100-300 mcg · Two to three times daily · 8-12 weeks

CJC-1295 with DAC

1000-2000 mcg · Once or twice weekly · 8-12 weeks

Tesamorelin dosing ranges

HIV lipodystrophy (FDA approved)

2000 mcg · Once daily (SubQ) · Ongoing as prescribed

Body composition / anti-aging (off-label)

1000-2000 mcg · Once daily · 8-12 weeks

CJC-1295 vs Tesamorelin — common questions

What is the difference between CJC-1295 and Tesamorelin?

CJC-1295: Long-acting growth hormone releasing hormone analog for sustained GH and IGF-1 elevation. Typical dose 100-300 mcg. Tesamorelin: FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity. Typical dose 1000-2000 mcg. Both fall under the Growth Hormone category.

Can you stack CJC-1295 and Tesamorelin?

Stacking CJC-1295 with Tesamorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, CJC-1295 or Tesamorelin?

CJC-1295 is typically dosed: Once to three times daily (SubQ) for Anti-aging and recovery (Mod GRF); Two to three times daily for Body composition (Mod GRF + Ipamorelin); Once or twice weekly for CJC-1295 with DAC. Tesamorelin is typically dosed: Once daily (SubQ) for HIV lipodystrophy (FDA approved); Once daily for Body composition / anti-aging (off-label).

Are CJC-1295 and Tesamorelin FDA approved?

CJC-1295: Not FDA approved for human use. Tesamorelin: FDA approved. Egrifta (tesamorelin) approved November 2010 for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Egrifta SV (reformulated single-vial) approved 2019.

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