Also known as: Testes Bioregulator, Testagen Khavinson Peptide
Half-life: Short (minutes); biological effect persists via gene-expression modulation
Last reviewed: · Published:
Testagen is a short peptide bioregulator from the Khavinson family, designed for testicular and male reproductive applications. It is proposed to target testicular Leydig cell and Sertoli cell gene expression to support testosterone production, spermatogenesis, and overall reproductive health in men. The compound has been used in Russian clinical settings for age-related testosterone decline, infertility evaluation, and recovery from testicular damage.
Russian clinical-observational studies have reported improvements in serum testosterone levels, sperm parameters, and subjective measures of vitality in elderly men and in male infertility populations. The mechanism is presumed to involve modulation of testicular gene expression via the broader Khavinson short-peptide bioregulator pathway, supporting Leydig-cell testosterone synthesis and Sertoli-cell support of spermatogenesis.
Testagen is sold by research-chemical vendors outside Russia. Western clinical data is essentially absent. The compound should not be used as a substitute for evaluation and management of hypogonadism by an endocrinologist or as a substitute for established fertility therapies. Self-experimentation in men with significant fertility concerns is not a substitute for proper clinical evaluation.
Testagen was developed in the 2000s as part of the Khavinson bioregulator program, with the testicular-targeting member of the family aimed at age-related testosterone decline, male infertility, and recovery from testicular injury. The compound entered Russian clinical observational use through the 2000s and 2010s.
Russian clinical use has reported good tolerability in male reproductive-health populations. Western safety validation is essentially absent. Men with significant hypogonadism or fertility concerns should undergo proper endocrinological evaluation before relying on any peptide bioregulator — the diagnostic distinction between primary testicular failure, secondary (hypothalamic-pituitary) hypogonadism, and age-related decline matters for treatment selection.
Dose Range
1-5 mg
Frequency
Once daily (SubQ) or sublingual
Duration
10-20 day cycles, repeated 2-3 times per year
Dosing information is for educational purposes only. Consult a healthcare professional before using any peptide.
Typical Vial Size
20 mg
Water Type
Bacteriostatic water (BAC water)
Mixing Volume
2 mL
Half-Life
Short (minutes); biological effect persists via gene-expression modulation
Molecular Weight
~400-600 Da
Store reconstituted vial refrigerated at 2-8°C. Use within 21-30 days. Sublingual or subcutaneous administration is typical.
FDA Status
Not FDA approved.
Legal Status
Unregulated research chemical outside Russia.
USA
Not approvedResearch-only
EU
Not approvedNot authorized as medicinal product
UK
Not approvedClassified as research chemical
Russia
Used in clinical practiceUsed as bioregulator in Russian endocrinology and reproductive medicine
Australia
Not approvedTGA has not evaluated
Canada
Not approvedNot authorized for human use
Khavinson VK, Kuznik BI, Tarnovskaya SI, Linkova NS
Bulletin of Experimental Biology and Medicine (2015)
Foundational Khavinson-group review covering the full short-peptide bioregulator family including Testagen.
View Study →Khavinson VK, Anisimov VN, Linkova NS, Bakhmet AA
Bulletin of Experimental Biology and Medicine (2020)
Modern Khavinson-group mechanistic review applicable to all tissue-targeting bioregulators including Testagen.
View Study →Khavinson VK, Kuznik BI, Linkova NS
Advances in Gerontology (2019)
Russian-group review of peptide bioregulators in endocrinological applications including Testagen and the broader testicular-support context.
View Study →Khavinson short peptide bioregulator targeting prostate tissue.
Khavinson short peptide bioregulator targeting pancreatic tissue and glucose metabolism.
Master upstream regulator of the reproductive axis — the GnRH releaser.
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