PinnyPeptide

TB-500 vs VIP (Vasoactive Intestinal Peptide)

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

TB-500

Healing & Recovery

Synthetic fragment of Thymosin Beta-4 with potent tissue repair activity.

Peptide B

VIP (Vasoactive Intestinal Peptide)

Healing & Recovery

Broad neuropeptide with anti-inflammatory, immunomodulatory, and vasodilatory activity.

Typical vial

5 mg

Typical dose

2000-5000 mcg

Half-life

~6-8 hours

FDA status

Not FDA approved for human use.

Typical vial

5 mg

Typical dose

50-200 (intranasal) mcg

Half-life

~2 minutes (plasma); longer functional duration via tissue distribution

FDA status

Not FDA approved as therapeutic. VIP analog aviptadil receiv…

TB-500 effects

  • Promotes wound healing and tissue repair
  • Reduces inflammation and fibrosis
  • Stimulates new blood vessel growth
  • Supports cardiac repair after ischemic injury
  • Enhances cell migration through actin upregulation

VIP (Vasoactive Intestinal Peptide) effects

  • Vasodilation and smooth-muscle relaxation
  • Broad anti-inflammatory effects via VPAC1/VPAC2
  • Immunomodulatory: shifts T-helper balance toward Th2/regulatory
  • Circadian rhythm organization (suprachiasmatic nucleus activity)
  • Lung-protective effects in ARDS and pulmonary hypertension models
  • Used clinically in CIRS / biotoxin-illness recovery protocols

TB-500 side effects

  • Injection site irritation
  • Temporary head rush or lightheadedness
  • Mild lethargy
  • Headache

VIP (Vasoactive Intestinal Peptide) side effects

  • Hypotension and flushing (especially with rapid IV)
  • Tachycardia
  • Headache
  • GI effects (cramping, diarrhea at high doses)
  • Intranasal: occasional nasal irritation

TB-500 dosing ranges

Acute injury healing

2000-5000 mcg · Twice weekly · 4-6 weeks

Maintenance and recovery

2000 mcg · Once weekly · 4-8 weeks

VIP (Vasoactive Intestinal Peptide) dosing ranges

Intranasal CIRS protocol (off-label)

50 mcg · 4 sprays daily · Per Shoemaker protocol; months to years for full restoration

Research / immunomodulation

Variable per protocol · Per protocol · Per protocol

Full TB-500 guide → Full VIP (Vasoactive Intestinal Peptide) guide →

TB-500 vs VIP (Vasoactive Intestinal Peptide) — common questions

What is the difference between TB-500 and VIP (Vasoactive Intestinal Peptide)?

TB-500: Synthetic fragment of Thymosin Beta-4 with potent tissue repair activity. Typical dose 2000-5000 mcg. VIP (Vasoactive Intestinal Peptide): Broad neuropeptide with anti-inflammatory, immunomodulatory, and vasodilatory activity. Typical dose 50-200 (intranasal) mcg. Both fall under the Healing & Recovery category.

Can you stack TB-500 and VIP (Vasoactive Intestinal Peptide)?

Stacking TB-500 with VIP (Vasoactive Intestinal Peptide) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, TB-500 or VIP (Vasoactive Intestinal Peptide)?

TB-500 is typically dosed: Twice weekly for Acute injury healing; Once weekly for Maintenance and recovery. VIP (Vasoactive Intestinal Peptide) is typically dosed: 4 sprays daily for Intranasal CIRS protocol (off-label); Per protocol for Research / immunomodulation.

Are TB-500 and VIP (Vasoactive Intestinal Peptide) FDA approved?

TB-500: Not FDA approved for human use. VIP (Vasoactive Intestinal Peptide): Not FDA approved as therapeutic. VIP analog aviptadil received Emergency Use Authorization consideration for COVID-19 ARDS but not full approval.

Related peptide comparisons

ara-290 vs tb-500b7-33 vs tb-500bpc-157 vs tb-500ghk-cu vs tb-500kpv vs tb-500ll-37 vs tb-500

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free