Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Growth Hormone
A locally-acting IGF-1 splice variant released by muscle in response to mechanical load.
Peptide B
Growth Hormone
FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity.
Typical vial
2 mg
Typical dose
200-400 mcg
Half-life
~5-7 minutes (MGF); ~2-3 days (PEG-MGF)
FDA status
Not FDA approved for any indication.
Typical vial
2 mg
Typical dose
1000-2000 mcg
Half-life
~26 minutes
FDA status
FDA approved. Egrifta (tesamorelin) approved November 2010 f…
MGF (Mechano Growth Factor) effects
Tesamorelin effects
MGF (Mechano Growth Factor) side effects
Tesamorelin side effects
MGF (Mechano Growth Factor) dosing ranges
Localized muscle repair (non-pegylated)
200-300 mcg per site · Post-workout, into the worked muscle (intramuscular) · 3-4 weeks per cycle
Systemic muscle recovery (PEG-MGF)
200-400 mcg · Twice weekly (SubQ) · 4-6 weeks per cycle
Tesamorelin dosing ranges
HIV lipodystrophy (FDA approved)
2000 mcg · Once daily (SubQ) · Ongoing as prescribed
Body composition / anti-aging (off-label)
1000-2000 mcg · Once daily · 8-12 weeks
MGF (Mechano Growth Factor): A locally-acting IGF-1 splice variant released by muscle in response to mechanical load. Typical dose 200-400 mcg. Tesamorelin: FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity. Typical dose 1000-2000 mcg. Both fall under the Growth Hormone category.
Stacking MGF (Mechano Growth Factor) with Tesamorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
MGF (Mechano Growth Factor) is typically dosed: Post-workout, into the worked muscle (intramuscular) for Localized muscle repair (non-pegylated); Twice weekly (SubQ) for Systemic muscle recovery (PEG-MGF). Tesamorelin is typically dosed: Once daily (SubQ) for HIV lipodystrophy (FDA approved); Once daily for Body composition / anti-aging (off-label).
MGF (Mechano Growth Factor): Not FDA approved for any indication. Tesamorelin: FDA approved. Egrifta (tesamorelin) approved November 2010 for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Egrifta SV (reformulated single-vial) approved 2019.
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