PinnyPeptide

GHRP-6 vs Tesamorelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

GHRP-6

Growth Hormone

First-generation ghrelin mimetic — potent GH release with notable appetite stimulation.

Peptide B

Tesamorelin

Growth Hormone

FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity.

Typical vial

5 mg

Typical dose

100 mcg

Half-life

~15-60 minutes

FDA status

Not FDA approved for any indication.

Typical vial

2 mg

Typical dose

1000-2000 mcg

Half-life

~26 minutes

FDA status

FDA approved. Egrifta (tesamorelin) approved November 2010 f…

GHRP-6 effects

  • Stimulates strong pulsatile growth hormone release
  • Markedly increases appetite via ghrelin-receptor activation
  • Synergizes with GHRH analogs (Sermorelin, CJC-1295)
  • Modest gains in lean mass and recovery over multi-week courses
  • May promote tissue repair via secondary IGF-1 elevation

Tesamorelin effects

  • FDA-proven reduction of visceral adipose tissue
  • Stimulates physiological pulsatile GH release
  • Improves body composition by reducing trunk fat
  • May enhance cognitive function in older adults
  • Increases IGF-1 levels
  • Does not significantly affect glucose homeostasis at approved doses

GHRP-6 side effects

  • Pronounced hunger within 30-60 minutes of injection
  • Increased prolactin and cortisol (more than newer GHRPs)
  • Water retention and mild edema
  • Injection-site flushing or tingling
  • Lethargy or tiredness shortly after dosing

Tesamorelin side effects

  • Injection site reactions (erythema, pruritus, pain)
  • Arthralgia (joint pain)
  • Peripheral edema
  • Myalgia (muscle pain)
  • Hypersensitivity reactions (rare)
  • Potential increase in IGF-1 above normal range

GHRP-6 dosing ranges

GH stimulation / recovery

100 mcg · Two to three times daily (SubQ) · 8-12 weeks, then break

Combined with CJC-1295 (Mod GRF)

100 mcg of each · Two to three times daily · 8-12 weeks

Appetite stimulation in cachexia research

100-150 mcg · Before meals · Per protocol

Tesamorelin dosing ranges

HIV lipodystrophy (FDA approved)

2000 mcg · Once daily (SubQ) · Ongoing as prescribed

Body composition / anti-aging (off-label)

1000-2000 mcg · Once daily · 8-12 weeks

GHRP-6 vs Tesamorelin — common questions

What is the difference between GHRP-6 and Tesamorelin?

GHRP-6: First-generation ghrelin mimetic — potent GH release with notable appetite stimulation. Typical dose 100 mcg. Tesamorelin: FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity. Typical dose 1000-2000 mcg. Both fall under the Growth Hormone category.

Can you stack GHRP-6 and Tesamorelin?

Stacking GHRP-6 with Tesamorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, GHRP-6 or Tesamorelin?

GHRP-6 is typically dosed: Two to three times daily (SubQ) for GH stimulation / recovery; Two to three times daily for Combined with CJC-1295 (Mod GRF); Before meals for Appetite stimulation in cachexia research. Tesamorelin is typically dosed: Once daily (SubQ) for HIV lipodystrophy (FDA approved); Once daily for Body composition / anti-aging (off-label).

Are GHRP-6 and Tesamorelin FDA approved?

GHRP-6: Not FDA approved for any indication. Tesamorelin: FDA approved. Egrifta (tesamorelin) approved November 2010 for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Egrifta SV (reformulated single-vial) approved 2019.

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free