PinnyPeptide

AOD-9604 vs Tesamorelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

AOD-9604

Weight Management

Fat-metabolizing fragment of human growth hormone without growth-promoting effects.

Peptide B

Tesamorelin

Growth Hormone

FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~30-60 minutes

FDA status

Not FDA approved as a drug. Granted GRAS status as a food ad…

Typical vial

2 mg

Typical dose

1000-2000 mcg

Half-life

~26 minutes

FDA status

FDA approved. Egrifta (tesamorelin) approved November 2010 f…

AOD-9604 effects

  • Stimulates lipolysis (fat breakdown) in adipose tissue
  • Inhibits lipogenesis (new fat formation)
  • Does not affect blood glucose or insulin levels
  • Does not elevate IGF-1 or bind the GH receptor
  • May support cartilage repair (emerging research)

Tesamorelin effects

  • FDA-proven reduction of visceral adipose tissue
  • Stimulates physiological pulsatile GH release
  • Improves body composition by reducing trunk fat
  • May enhance cognitive function in older adults
  • Increases IGF-1 levels
  • Does not significantly affect glucose homeostasis at approved doses

AOD-9604 side effects

  • Injection site irritation or redness
  • Occasional headache
  • Mild nausea (uncommon)
  • Transient lightheadedness

Tesamorelin side effects

  • Injection site reactions (erythema, pruritus, pain)
  • Arthralgia (joint pain)
  • Peripheral edema
  • Myalgia (muscle pain)
  • Hypersensitivity reactions (rare)
  • Potential increase in IGF-1 above normal range

AOD-9604 dosing ranges

Fat loss and body composition

250-500 mcg · Once daily (SubQ) · 8-12 weeks

Tesamorelin dosing ranges

HIV lipodystrophy (FDA approved)

2000 mcg · Once daily (SubQ) · Ongoing as prescribed

Body composition / anti-aging (off-label)

1000-2000 mcg · Once daily · 8-12 weeks

AOD-9604 vs Tesamorelin — common questions

What is the difference between AOD-9604 and Tesamorelin?

AOD-9604: Fat-metabolizing fragment of human growth hormone without growth-promoting effects. Typical dose 250-500 mcg. Tesamorelin: FDA-approved GHRH analog for HIV-associated lipodystrophy with potent GH-releasing activity. Typical dose 1000-2000 mcg. Both fall under the Weight Management and Growth Hormone categories.

Can you stack AOD-9604 and Tesamorelin?

Stacking AOD-9604 with Tesamorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, AOD-9604 or Tesamorelin?

AOD-9604 is typically dosed: Once daily (SubQ) for Fat loss and body composition. Tesamorelin is typically dosed: Once daily (SubQ) for HIV lipodystrophy (FDA approved); Once daily for Body composition / anti-aging (off-label).

Are AOD-9604 and Tesamorelin FDA approved?

AOD-9604: Not FDA approved as a drug. Granted GRAS status as a food additive in 2014. Tesamorelin: FDA approved. Egrifta (tesamorelin) approved November 2010 for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Egrifta SV (reformulated single-vial) approved 2019.

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