PinnyPeptide

Epithalon vs Vilon

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Epithalon

Longevity

Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production.

Peptide B

Vilon

Bioregulators

Khavinson Lys-Glu dipeptide — immunomodulator with documented life-extension activity in mice.

Typical vial

10 mg

Typical dose

5000-10000 mcg

Half-life

~30 minutes (short half-life but biological effects persist due to gene expression changes)

FDA status

Not FDA approved for human use. No clinical trials submitted…

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Epithalon effects

  • Activates telomerase enzyme to elongate telomeres
  • Restores melatonin production in the pineal gland
  • Regulates neuroendocrine function and circadian rhythms
  • Reduces incidence of spontaneous tumors in animal models
  • Modulates gene expression patterns associated with aging

Vilon effects

  • Reported immunomodulatory effects
  • Life-extension and tumor-reduction in mouse studies (Khavinson group)
  • Possible telomere-related activity
  • Support of T-cell function in elderly populations
  • Modulation of immune gene expression

Epithalon side effects

  • Mild injection site irritation
  • Occasional drowsiness (related to melatonin effects)
  • Rare mild headache
  • Transient changes in sleep patterns

Vilon side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Caution in active autoimmune disease

Epithalon dosing ranges

Anti-aging and telomere support

5-10 mg · Once daily (SubQ) · 10-20 days, repeated 1-2 times per year

Vilon dosing ranges

Immune support / anti-aging research

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Full Epithalon guide → Full Vilon guide →

Epithalon vs Vilon — common questions

What is the difference between Epithalon and Vilon?

Epithalon: Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production. Typical dose 5000-10000 mcg. Vilon: Khavinson Lys-Glu dipeptide — immunomodulator with documented life-extension activity in mice. Typical dose 1,000-5,000 mcg. Both fall under the Longevity and Bioregulators categories.

Can you stack Epithalon and Vilon?

Stacking Epithalon with Vilon is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Epithalon or Vilon?

Epithalon is typically dosed: Once daily (SubQ) for Anti-aging and telomere support. Vilon is typically dosed: Once daily (SubQ) or sublingual for Immune support / anti-aging research.

Are Epithalon and Vilon FDA approved?

Epithalon: Not FDA approved for human use. No clinical trials submitted to the FDA. Vilon: Not FDA approved.

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