PinnyPeptide

Epithalon vs SS-31 (Elamipretide)

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Epithalon

Longevity

Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production.

Peptide B

SS-31 (Elamipretide)

Longevity

Mitochondria-targeted tetrapeptide that restores bioenergetics by stabilizing cardiolipin.

Typical vial

10 mg

Typical dose

5000-10000 mcg

Half-life

~30 minutes (short half-life but biological effects persist due to gene expression changes)

FDA status

Not FDA approved for human use. No clinical trials submitted…

Typical vial

5 mg

Typical dose

5000-50000 mcg

Half-life

~4 hours

FDA status

Not FDA approved. FDA declined approval for Barth syndrome i…

Epithalon effects

  • Activates telomerase enzyme to elongate telomeres
  • Restores melatonin production in the pineal gland
  • Regulates neuroendocrine function and circadian rhythms
  • Reduces incidence of spontaneous tumors in animal models
  • Modulates gene expression patterns associated with aging

SS-31 (Elamipretide) effects

  • Stabilizes cardiolipin at the mitochondrial inner membrane
  • Restores electron transport chain efficiency and ATP production
  • Reduces mitochondrial ROS production at the source
  • Protects against ischemia-reperfusion injury in heart and kidney
  • Improves age-related mitochondrial dysfunction

Epithalon side effects

  • Mild injection site irritation
  • Occasional drowsiness (related to melatonin effects)
  • Rare mild headache
  • Transient changes in sleep patterns

SS-31 (Elamipretide) side effects

  • Injection site reactions (pain, redness)
  • Mild headache
  • Transient flushing
  • Occasional dizziness

Epithalon dosing ranges

Anti-aging and telomere support

5-10 mg · Once daily (SubQ) · 10-20 days, repeated 1-2 times per year

SS-31 (Elamipretide) dosing ranges

Mitochondrial support and longevity

5-50 mg · Once daily (SubQ) · 4-12 weeks

Full Epithalon guide → Full SS-31 (Elamipretide) guide →

Epithalon vs SS-31 (Elamipretide) — common questions

What is the difference between Epithalon and SS-31 (Elamipretide)?

Epithalon: Synthetic pineal tetrapeptide that activates telomerase and modulates melatonin production. Typical dose 5000-10000 mcg. SS-31 (Elamipretide): Mitochondria-targeted tetrapeptide that restores bioenergetics by stabilizing cardiolipin. Typical dose 5000-50000 mcg. Both fall under the Longevity category.

Can you stack Epithalon and SS-31 (Elamipretide)?

Stacking Epithalon with SS-31 (Elamipretide) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Epithalon or SS-31 (Elamipretide)?

Epithalon is typically dosed: Once daily (SubQ) for Anti-aging and telomere support. SS-31 (Elamipretide) is typically dosed: Once daily (SubQ) for Mitochondrial support and longevity.

Are Epithalon and SS-31 (Elamipretide) FDA approved?

Epithalon: Not FDA approved for human use. No clinical trials submitted to the FDA. SS-31 (Elamipretide): Not FDA approved. FDA declined approval for Barth syndrome in 2023, requesting additional efficacy data. Multiple clinical trials ongoing for other mitochondrial indications.

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