PinnyPeptide

DSIP vs Selank

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

DSIP

Sleep

Endogenous nonapeptide that promotes delta wave sleep and modulates neuroendocrine stress responses.

Peptide B

Selank

Cognitive

Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties.

Typical vial

5 mg

Typical dose

100-300 mcg

Half-life

~7-8 minutes (rapidly degraded by aminopeptidases)

FDA status

Not FDA approved for human use. No clinical trials submitted…

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~15-30 minutes (extended biological effect due to downstream signaling)

FDA status

Not FDA approved for human use.

DSIP effects

  • Promotes delta wave (deep) sleep without suppressing REM
  • Modulates HPA axis to reduce cortisol during stress
  • Influences pain perception through opioid system interactions
  • May normalize blood pressure in hypertensive states
  • Exhibits neuroprotective properties under oxidative stress

Selank effects

  • Reduces anxiety without sedation or cognitive impairment
  • Enhances memory consolidation and learning
  • Modulates serotonin, dopamine, and GABA neurotransmitter systems
  • Provides immunomodulatory effects through cytokine balance regulation
  • Increases brain-derived neurotrophic factor (BDNF) expression

DSIP side effects

  • Daytime drowsiness if taken at inappropriate times
  • Mild headache (uncommon)
  • Transient hypotension (rare)
  • Vivid dreams (frequently reported anecdotally)

Selank side effects

  • Mild nasal irritation (intranasal administration)
  • Fatigue during initial use (transient)
  • Occasional lightheadedness

DSIP dosing ranges

Sleep support

100-300 mcg · Once daily, 30-60 minutes before bedtime (SubQ) · 2-4 weeks

Stress and cortisol modulation

100-200 mcg · Once daily (SubQ) · 2-4 weeks

Selank dosing ranges

Anxiolytic and cognitive enhancement (intranasal)

250-500 mcg · Two to three times daily · 2-4 weeks

Subcutaneous injection

250-500 mcg · Once daily · 2-4 weeks

Full DSIP guide → Full Selank guide →

DSIP vs Selank — common questions

What is the difference between DSIP and Selank?

DSIP: Endogenous nonapeptide that promotes delta wave sleep and modulates neuroendocrine stress responses. Typical dose 100-300 mcg. Selank: Russian-approved anxiolytic peptide derived from tuftsin with nootropic and immunomodulatory properties. Typical dose 250-500 mcg. Both fall under the Sleep and Cognitive categories.

Can you stack DSIP and Selank?

Stacking DSIP with Selank is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, DSIP or Selank?

DSIP is typically dosed: Once daily, 30-60 minutes before bedtime (SubQ) for Sleep support; Once daily (SubQ) for Stress and cortisol modulation. Selank is typically dosed: Two to three times daily for Anxiolytic and cognitive enhancement (intranasal); Once daily for Subcutaneous injection.

Are DSIP and Selank FDA approved?

DSIP: Not FDA approved for human use. No clinical trials submitted for FDA review. Selank: Not FDA approved for human use.

Related peptide comparisons

dsip vs epithalondsip vs orexin-adsip vs orexin-bdsip vs pinealondsip vs pt-141acth-1-39 vs selank

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free