PinnyPeptide

Thymagen vs Thymosin Alpha-1

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Thymagen

Bioregulators

Khavinson short peptide bioregulator targeting thymic function — Glu-Trp synthetic version.

Peptide B

Thymosin Alpha-1

Immune

Thymic peptide with broad immunomodulatory activity, approved in over 35 countries.

Typical vial

20 mg

Typical dose

1,000-5,000 mcg

Half-life

Short (minutes); biological effect persists via gene-expression modulation

FDA status

Not FDA approved.

Typical vial

5 mg

Typical dose

1000-1600 mcg

Half-life

~2 hours

FDA status

Not FDA approved. Granted orphan drug designation for hepato…

Thymagen effects

  • Reported improvement in T-cell function and number
  • Support of thymic function in aging populations
  • Recovery support after severe illness
  • Anti-inflammatory effects
  • Modulation of immune gene expression

Thymosin Alpha-1 effects

  • Enhances T-cell maturation and differentiation
  • Activates natural killer cell cytotoxicity
  • Stimulates dendritic cell function and antigen presentation
  • Modulates cytokine production (IFN-alpha, IL-2)
  • Improves vaccine response in immunocompromised patients

Thymagen side effects

  • Generally well-tolerated in Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Caution in active autoimmune disease

Thymosin Alpha-1 side effects

  • Mild injection site discomfort
  • Transient flu-like symptoms during initial immune activation
  • Occasional fatigue
  • Rare mild fever

Thymagen dosing ranges

Immune support

1-5 mg · Once daily (SubQ) or sublingual · 10-20 day cycles, repeated 2-3 times per year

Thymosin Alpha-1 dosing ranges

Immune modulation

1000-1600 mcg · Twice weekly (SubQ) · 6-12 months

Hepatitis treatment (clinical protocol)

1600 mcg · Twice weekly · 6-12 months

Acute immune support

1600 mcg · Daily for initial phase, then twice weekly · 2-4 weeks acute, then maintenance

Thymagen vs Thymosin Alpha-1 — common questions

What is the difference between Thymagen and Thymosin Alpha-1?

Thymagen: Khavinson short peptide bioregulator targeting thymic function — Glu-Trp synthetic version. Typical dose 1,000-5,000 mcg. Thymosin Alpha-1: Thymic peptide with broad immunomodulatory activity, approved in over 35 countries. Typical dose 1000-1600 mcg. Both fall under the Bioregulators and Immune categories.

Can you stack Thymagen and Thymosin Alpha-1?

Stacking Thymagen with Thymosin Alpha-1 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Thymagen or Thymosin Alpha-1?

Thymagen is typically dosed: Once daily (SubQ) or sublingual for Immune support. Thymosin Alpha-1 is typically dosed: Twice weekly (SubQ) for Immune modulation; Twice weekly for Hepatitis treatment (clinical protocol); Daily for initial phase, then twice weekly for Acute immune support.

Are Thymagen and Thymosin Alpha-1 FDA approved?

Thymagen: Not FDA approved. Thymosin Alpha-1: Not FDA approved. Granted orphan drug designation for hepatocellular carcinoma and hepatitis B. Multiple clinical trials conducted but no NDA submitted.

Tracking either of these?

Log doses, automate injection site rotation, and never lose track of where you last pinned. Free forever.

Get Started Free