PinnyPeptide

TB-500 vs TB-500 Fragment 17-23

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

TB-500

Healing & Recovery

Synthetic fragment of Thymosin Beta-4 with potent tissue repair activity.

Peptide B

TB-500 Fragment 17-23

Healing & Recovery

The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects.

Typical vial

5 mg

Typical dose

2000-5000 mcg

Half-life

~6-8 hours

FDA status

Not FDA approved for human use.

Typical vial

10 mg

Typical dose

2000-5000 mcg

Half-life

Estimated minutes to a few hours (much shorter than full TB-500 due to lack of N/C-terminal protection)

FDA status

Not FDA approved for any human or veterinary use. No clinica…

TB-500 effects

  • Promotes wound healing and tissue repair
  • Reduces inflammation and fibrosis
  • Stimulates new blood vessel growth
  • Supports cardiac repair after ischemic injury
  • Enhances cell migration through actin upregulation

TB-500 Fragment 17-23 effects

  • Binds G-actin and modulates actin polymerization
  • In vitro promotion of keratinocyte and endothelial cell migration
  • Pro-angiogenic activity in cell-based assays
  • Pro-healing effects on cultured fibroblasts
  • Anti-inflammatory effects (limited to in vitro evidence)
  • Potentially shared but reduced systemic activity vs full TB-500

TB-500 side effects

  • Injection site irritation
  • Temporary head rush or lightheadedness
  • Mild lethargy
  • Headache

TB-500 Fragment 17-23 side effects

  • Injection site irritation or redness
  • Lethargy (anecdotal, mechanism unclear)
  • Mild flu-like symptoms at higher doses (rare)
  • Headache
  • Unknown long-term effects — no human safety data

TB-500 dosing ranges

Acute injury healing

2000-5000 mcg · Twice weekly · 4-6 weeks

Maintenance and recovery

2000 mcg · Once weekly · 4-8 weeks

TB-500 Fragment 17-23 dosing ranges

Injury recovery (extrapolated)

2-5 mg · Twice weekly SubQ · 4-6 weeks

Tendon/ligament support (extrapolated)

2-5 mg · Twice weekly SubQ · 4-8 weeks

Loading phase (anecdotal)

5 mg · Twice weekly for 2-3 weeks · Then maintenance

Full TB-500 guide → Full TB-500 Fragment 17-23 guide →

TB-500 vs TB-500 Fragment 17-23 — common questions

What is the difference between TB-500 and TB-500 Fragment 17-23?

TB-500: Synthetic fragment of Thymosin Beta-4 with potent tissue repair activity. Typical dose 2000-5000 mcg. TB-500 Fragment 17-23: The 7-amino-acid active fragment of TB-500, isolated for cell-migration effects. Typical dose 2000-5000 mcg. Both fall under the Healing & Recovery category.

Can you stack TB-500 and TB-500 Fragment 17-23?

Stacking TB-500 with TB-500 Fragment 17-23 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, TB-500 or TB-500 Fragment 17-23?

TB-500 is typically dosed: Twice weekly for Acute injury healing; Once weekly for Maintenance and recovery. TB-500 Fragment 17-23 is typically dosed: Twice weekly SubQ for Injury recovery (extrapolated); Twice weekly SubQ for Tendon/ligament support (extrapolated); Twice weekly for 2-3 weeks for Loading phase (anecdotal).

Are TB-500 and TB-500 Fragment 17-23 FDA approved?

TB-500: Not FDA approved for human use. TB-500 Fragment 17-23: Not FDA approved for any human or veterinary use. No clinical trials have been conducted on this specific fragment.

Related peptide comparisons

ara-290 vs tb-500b7-33 vs tb-500bpc-157 vs tb-500ghk-cu vs tb-500kpv vs tb-500ll-37 vs tb-500

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