PinnyPeptide

HEP-1 (Gepon) vs Thymalin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

HEP-1 (Gepon)

Immune

Russian-approved 14-amino-acid immunomodulator derived from the ezrin protein.

Peptide B

Thymalin

Bioregulators

Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record.

Typical vial

5 mg

Typical dose

1,000-10,000 mcg

Half-life

Variable per route

FDA status

Not FDA approved. Approved in Russia as Gepon.

Typical vial

10 mg

Typical dose

5,000-30,000 mcg

Half-life

Variable (peptide complex)

FDA status

Not FDA approved.

HEP-1 (Gepon) effects

  • Macrophage activation and cytokine modulation
  • Enhanced mucosal immune defense
  • Antiviral activity in HIV, herpes, hepatitis (Russian clinical use)
  • Anti-inflammatory effects in chronic infectious conditions
  • Restoration of immune function in immunocompromised patients

Thymalin effects

  • Reported improvement in T-cell numbers (especially CD4+)
  • Improvement in CD4/CD8 ratio
  • Enhanced NK-cell function
  • Reduction in infection rates in immunocompromised patients
  • Long-term observational reduction in mortality (Khavinson 2003 study)
  • Anti-inflammatory effects

HEP-1 (Gepon) side effects

  • Generally well-tolerated in Russian clinical use
  • Mild local irritation with topical or intranasal use
  • Occasional headache
  • Rare allergic reactions
  • Long-term safety with chronic use not extensively studied outside Russia

Thymalin side effects

  • Generally well-tolerated across 40 years of Russian clinical use
  • Mild injection-site reactions
  • Limited Western safety validation
  • Caution in active autoimmune disease

HEP-1 (Gepon) dosing ranges

HIV/AIDS adjunct (Russian clinical)

10 mg · Once daily, oral or rectal · Per clinical protocol

Recurrent herpes (Russian clinical)

2 mg · Topical 3-4 times daily · 7-14 days per outbreak

Mucosal immunity research

1-5 mg · Intranasal or oral · Per research protocol

Thymalin dosing ranges

Immune support (Russian clinical)

5-30 mg · Once daily IM or SubQ · 5-10 day course, repeated 2-3 times per year

Full HEP-1 (Gepon) guide → Full Thymalin guide →

HEP-1 (Gepon) vs Thymalin — common questions

What is the difference between HEP-1 (Gepon) and Thymalin?

HEP-1 (Gepon): Russian-approved 14-amino-acid immunomodulator derived from the ezrin protein. Typical dose 1,000-10,000 mcg. Thymalin: Original Khavinson thymic peptide complex — multi-peptide immunomodulator with 40-year Russian clinical track record. Typical dose 5,000-30,000 mcg. Both fall under the Immune and Bioregulators categories.

Can you stack HEP-1 (Gepon) and Thymalin?

Stacking HEP-1 (Gepon) with Thymalin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, HEP-1 (Gepon) or Thymalin?

HEP-1 (Gepon) is typically dosed: Once daily, oral or rectal for HIV/AIDS adjunct (Russian clinical); Topical 3-4 times daily for Recurrent herpes (Russian clinical); Intranasal or oral for Mucosal immunity research. Thymalin is typically dosed: Once daily IM or SubQ for Immune support (Russian clinical).

Are HEP-1 (Gepon) and Thymalin FDA approved?

HEP-1 (Gepon): Not FDA approved. Approved in Russia as Gepon. Thymalin: Not FDA approved.

Related peptide comparisons

hep-1 vs thymosin-alpha-1hep-1 vs vilonhep-1 vs vipbronchogen vs thymalincardiogen vs thymalincartalax vs thymalin

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